Radiation-Associated Toxicities in Obese Women with Endometrial Cancer: More Than Just BMI?
Purpose. The study characterizes the impact of obesity on postoperative radiation-associated toxicities in women with endometrial cancer (EC). Material and Methods. A retrospective study identified 96 women with EC referred to a large urban institution’s radiation oncology practice for postoperative...
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| Language: | English |
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Wiley
2015-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2015/483208 |
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| author | Savita V. Dandapani Ying Zhang Richard Jennelle Yvonne G. Lin |
| author_facet | Savita V. Dandapani Ying Zhang Richard Jennelle Yvonne G. Lin |
| author_sort | Savita V. Dandapani |
| collection | DOAJ |
| description | Purpose. The study characterizes the impact of obesity on postoperative radiation-associated toxicities in women with endometrial cancer (EC). Material and Methods. A retrospective study identified 96 women with EC referred to a large urban institution’s radiation oncology practice for postoperative whole pelvic radiotherapy (WPRT) and/or intracavitary vaginal brachytherapy (ICBT). Demographic and clinicopathologic data were obtained. Toxicities were graded according to RTOG Acute Radiation Morbidity Scoring Criteria. Follow-up period ranged from 1 month to 11 years (median 2 years). Data were analyzed by χ2, logistic regression, and recursive partitioning analyses. Results. 68 EC patients who received WPRT and/or ICBT were analyzed. Median age was 52 years (29–73). The majority were Hispanic (71%). Median BMI at diagnosis was 34.5 kg/m2 (20.5–56.6 kg/m2). BMI was independently associated with radiation-related cutaneous (p=0.022) and gynecologic-related (p=0.027) toxicities. Younger women also reported more gynecologic-related toxicities (p=0.039). Adjuvant radiation technique was associated with increased gastrointestinal- and genitourinary-related toxicities but not gynecologic-related toxicity. Conclusions. Increasing BMI was associated with increased frequency of gynecologic and cutaneous radiation-associated toxicities. Additional studies to critically evaluate the radiation treatment dosing and treatment fields in obese EC patients are warranted to identify strategies to mitigate the radiation-associated toxicities in these women. |
| format | Article |
| id | doaj-art-556bacdee4f14d57ba407235ca4658fd |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-556bacdee4f14d57ba407235ca4658fd2025-02-03T01:01:51ZengWileyThe Scientific World Journal2356-61401537-744X2015-01-01201510.1155/2015/483208483208Radiation-Associated Toxicities in Obese Women with Endometrial Cancer: More Than Just BMI?Savita V. Dandapani0Ying Zhang1Richard Jennelle2Yvonne G. Lin3Department of Radiation Oncology, City of Hope, Duarte, CA 91010, USADepartment of Radiation Oncology, University of Southern California, Los Angeles, CA 90033, USADepartment of Radiation Oncology, University of Southern California, Los Angeles, CA 90033, USADepartment of Gynecologic Oncology, Obstetrics-Gynecology, University of Southern California, Los Angeles, CA 90033, USAPurpose. The study characterizes the impact of obesity on postoperative radiation-associated toxicities in women with endometrial cancer (EC). Material and Methods. A retrospective study identified 96 women with EC referred to a large urban institution’s radiation oncology practice for postoperative whole pelvic radiotherapy (WPRT) and/or intracavitary vaginal brachytherapy (ICBT). Demographic and clinicopathologic data were obtained. Toxicities were graded according to RTOG Acute Radiation Morbidity Scoring Criteria. Follow-up period ranged from 1 month to 11 years (median 2 years). Data were analyzed by χ2, logistic regression, and recursive partitioning analyses. Results. 68 EC patients who received WPRT and/or ICBT were analyzed. Median age was 52 years (29–73). The majority were Hispanic (71%). Median BMI at diagnosis was 34.5 kg/m2 (20.5–56.6 kg/m2). BMI was independently associated with radiation-related cutaneous (p=0.022) and gynecologic-related (p=0.027) toxicities. Younger women also reported more gynecologic-related toxicities (p=0.039). Adjuvant radiation technique was associated with increased gastrointestinal- and genitourinary-related toxicities but not gynecologic-related toxicity. Conclusions. Increasing BMI was associated with increased frequency of gynecologic and cutaneous radiation-associated toxicities. Additional studies to critically evaluate the radiation treatment dosing and treatment fields in obese EC patients are warranted to identify strategies to mitigate the radiation-associated toxicities in these women.http://dx.doi.org/10.1155/2015/483208 |
| spellingShingle | Savita V. Dandapani Ying Zhang Richard Jennelle Yvonne G. Lin Radiation-Associated Toxicities in Obese Women with Endometrial Cancer: More Than Just BMI? The Scientific World Journal |
| title | Radiation-Associated Toxicities in Obese Women with Endometrial Cancer: More Than Just BMI? |
| title_full | Radiation-Associated Toxicities in Obese Women with Endometrial Cancer: More Than Just BMI? |
| title_fullStr | Radiation-Associated Toxicities in Obese Women with Endometrial Cancer: More Than Just BMI? |
| title_full_unstemmed | Radiation-Associated Toxicities in Obese Women with Endometrial Cancer: More Than Just BMI? |
| title_short | Radiation-Associated Toxicities in Obese Women with Endometrial Cancer: More Than Just BMI? |
| title_sort | radiation associated toxicities in obese women with endometrial cancer more than just bmi |
| url | http://dx.doi.org/10.1155/2015/483208 |
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