Cardiac Magnetic Resonance to Reclassify Diagnosis and Detect Cardiomyopathies in Hospitalized Patients with Acute Presentation
Background: Cardiomyopathies are a significant cause of heart failure, arrhythmia, and cardiac morbidity in the general population. Cardiovascular magnetic resonance (CMR) is a valuable tool for the diagnostic work-up of patients with acute cardiac events. Objectives: This study evaluated the diagno...
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2025-03-01
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| author | Theodoros Tsampras Alexios Antonopoulos Alexandros Kasiakogias Alexia Mika Antonia Kolovou Eleni Papadimitriou George Lazaros Konstantinos Tsioufis Charalambos Vlachopoulos |
| author_facet | Theodoros Tsampras Alexios Antonopoulos Alexandros Kasiakogias Alexia Mika Antonia Kolovou Eleni Papadimitriou George Lazaros Konstantinos Tsioufis Charalambos Vlachopoulos |
| author_sort | Theodoros Tsampras |
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| description | Background: Cardiomyopathies are a significant cause of heart failure, arrhythmia, and cardiac morbidity in the general population. Cardiovascular magnetic resonance (CMR) is a valuable tool for the diagnostic work-up of patients with acute cardiac events. Objectives: This study evaluated the diagnostic value of CMR and the yield of cardiomyopathies in hospitalized cardiac patients with acute presentation. Methods: A retrospective analysis was conducted with 535 consecutive hospitalized patients who underwent CMR at Hippokration Hospital, Athens, Greece, to identify a subset of scans performed on an urgent basis of hospitalized patients. Demographic data, causes of admission, CMR findings, and plasma cardiac biomarkers (hs-Troponin I, NT-proBNP, and CRP) were systematically recorded. Results: Out of the initial 535 CMR scans evaluated, a further analysis was conducted with 104 patients who were in hospital and underwent CMR on an urgent basis. From the total population of hospitalized patients, 33% had CMR findings indicative of underlying cardiomyopathy, with dilated cardiomyopathy being the most common subtype (36%), followed by arrhythmogenic cardiomyopathy (27%), hypertrophic cardiomyopathy (15%), or other subtypes (e.g., cardiac amyloidosis, sarcoidosis, endomyocardial fibrosis, EGPA, or unclassified). CMR led to the reclassification of the initial diagnosis into that of underlying cardiomyopathy in 32% of cases. The highest reclassification rate was observed within the subgroup with heart failure (71%), followed by that of acute myocardial infarction/ischemic heart disease (24%) and myocarditis (22%). Conclusions: CMR imaging effectively contributed to the differential diagnosis of hospitalized patients with acute cardiac events that remained without a definitive diagnosis after their initial work-up and uncovered underlying cardiomyopathy in almost one-third of this cohort. |
| format | Article |
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| issn | 2075-1729 |
| language | English |
| publishDate | 2025-03-01 |
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| series | Life |
| spelling | doaj-art-556a3a9a17504ee2b20f704cd3a490442025-08-20T01:49:00ZengMDPI AGLife2075-17292025-03-0115347010.3390/life15030470Cardiac Magnetic Resonance to Reclassify Diagnosis and Detect Cardiomyopathies in Hospitalized Patients with Acute PresentationTheodoros Tsampras0Alexios Antonopoulos1Alexandros Kasiakogias2Alexia Mika3Antonia Kolovou4Eleni Papadimitriou5George Lazaros6Konstantinos Tsioufis7Charalambos Vlachopoulos81st Cardiology Department, Hippokration Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece1st Cardiology Department, Hippokration Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece1st Cardiology Department, Hippokration Hospital, National and Kapodistrian University of Athens, 11527 Athens, GreeceRadiology Department, Hippokration Hospital, 11527 Athens, GreeceRadiology Department, Hippokration Hospital, 11527 Athens, GreeceRadiology Department, Hippokration Hospital, 11527 Athens, Greece1st Cardiology Department, Hippokration Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece1st Cardiology Department, Hippokration Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece1st Cardiology Department, Hippokration Hospital, National and Kapodistrian University of Athens, 11527 Athens, GreeceBackground: Cardiomyopathies are a significant cause of heart failure, arrhythmia, and cardiac morbidity in the general population. Cardiovascular magnetic resonance (CMR) is a valuable tool for the diagnostic work-up of patients with acute cardiac events. Objectives: This study evaluated the diagnostic value of CMR and the yield of cardiomyopathies in hospitalized cardiac patients with acute presentation. Methods: A retrospective analysis was conducted with 535 consecutive hospitalized patients who underwent CMR at Hippokration Hospital, Athens, Greece, to identify a subset of scans performed on an urgent basis of hospitalized patients. Demographic data, causes of admission, CMR findings, and plasma cardiac biomarkers (hs-Troponin I, NT-proBNP, and CRP) were systematically recorded. Results: Out of the initial 535 CMR scans evaluated, a further analysis was conducted with 104 patients who were in hospital and underwent CMR on an urgent basis. From the total population of hospitalized patients, 33% had CMR findings indicative of underlying cardiomyopathy, with dilated cardiomyopathy being the most common subtype (36%), followed by arrhythmogenic cardiomyopathy (27%), hypertrophic cardiomyopathy (15%), or other subtypes (e.g., cardiac amyloidosis, sarcoidosis, endomyocardial fibrosis, EGPA, or unclassified). CMR led to the reclassification of the initial diagnosis into that of underlying cardiomyopathy in 32% of cases. The highest reclassification rate was observed within the subgroup with heart failure (71%), followed by that of acute myocardial infarction/ischemic heart disease (24%) and myocarditis (22%). Conclusions: CMR imaging effectively contributed to the differential diagnosis of hospitalized patients with acute cardiac events that remained without a definitive diagnosis after their initial work-up and uncovered underlying cardiomyopathy in almost one-third of this cohort.https://www.mdpi.com/2075-1729/15/3/470cardiomyopathycardiovascular magnetic resonanceheart failuremyocarditismyocardial infarction |
| spellingShingle | Theodoros Tsampras Alexios Antonopoulos Alexandros Kasiakogias Alexia Mika Antonia Kolovou Eleni Papadimitriou George Lazaros Konstantinos Tsioufis Charalambos Vlachopoulos Cardiac Magnetic Resonance to Reclassify Diagnosis and Detect Cardiomyopathies in Hospitalized Patients with Acute Presentation Life cardiomyopathy cardiovascular magnetic resonance heart failure myocarditis myocardial infarction |
| title | Cardiac Magnetic Resonance to Reclassify Diagnosis and Detect Cardiomyopathies in Hospitalized Patients with Acute Presentation |
| title_full | Cardiac Magnetic Resonance to Reclassify Diagnosis and Detect Cardiomyopathies in Hospitalized Patients with Acute Presentation |
| title_fullStr | Cardiac Magnetic Resonance to Reclassify Diagnosis and Detect Cardiomyopathies in Hospitalized Patients with Acute Presentation |
| title_full_unstemmed | Cardiac Magnetic Resonance to Reclassify Diagnosis and Detect Cardiomyopathies in Hospitalized Patients with Acute Presentation |
| title_short | Cardiac Magnetic Resonance to Reclassify Diagnosis and Detect Cardiomyopathies in Hospitalized Patients with Acute Presentation |
| title_sort | cardiac magnetic resonance to reclassify diagnosis and detect cardiomyopathies in hospitalized patients with acute presentation |
| topic | cardiomyopathy cardiovascular magnetic resonance heart failure myocarditis myocardial infarction |
| url | https://www.mdpi.com/2075-1729/15/3/470 |
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