hpvPDB: An Online Proteome Reserve for Human Papillomavirus

Human papillomavirus (HPV) infection is the leading cause of cancer mortality among women worldwide. The molecular understanding of HPV proteins has significant connotation for understanding their intrusion in the host and designing novel protein vaccines and anti-viral agents, etc. Genomic, proteom...

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Main Authors: Satish Kumar, Lingaraja Jena, Sangeeta Daf, Kanchan Mohod, Peyush Goyal, Ashok K. Varma
Format: Article
Language:English
Published: BioMed Central 2013-12-01
Series:Genomics & Informatics
Subjects:
Online Access:http://genominfo.org/upload/pdf/gni-11-289.pdf
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author Satish Kumar
Lingaraja Jena
Sangeeta Daf
Kanchan Mohod
Peyush Goyal
Ashok K. Varma
author_facet Satish Kumar
Lingaraja Jena
Sangeeta Daf
Kanchan Mohod
Peyush Goyal
Ashok K. Varma
author_sort Satish Kumar
collection DOAJ
description Human papillomavirus (HPV) infection is the leading cause of cancer mortality among women worldwide. The molecular understanding of HPV proteins has significant connotation for understanding their intrusion in the host and designing novel protein vaccines and anti-viral agents, etc. Genomic, proteomic, structural, and disease-related information on HPV is available on the web; yet, with trivial annotations and more so, it is not well customized for data analysis, host-pathogen interaction, strain-disease association, drug designing, and sequence analysis, etc. We attempted to design an online reserve with comprehensive information on HPV for the end users desiring the same. The Human Papillomavirus Proteome Database (hpvPDB) domiciles proteomic and genomic information on 150 HPV strains sequenced to date. Simultaneous easy expandability and retrieval of the strain-specific data, with a provision for sequence analysis and exploration potential of predicted structures, and easy access for curation and annotation through a range of search options at one platform are a few of its important features. Affluent information in this reserve could be of help for researchers involved in structural virology, cancer research, drug discovery, and vaccine design.
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publishDate 2013-12-01
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series Genomics & Informatics
spelling doaj-art-5569d59dc0c34f96b9813374c8bd874f2025-02-02T18:00:56ZengBioMed CentralGenomics & Informatics1598-866X2234-07422013-12-0111428929110.5808/GI.2013.11.4.28974hpvPDB: An Online Proteome Reserve for Human PapillomavirusSatish Kumar0Lingaraja Jena1Sangeeta Daf2Kanchan Mohod3Peyush Goyal4Ashok K. Varma5Bioinformatics Centre and Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram 442-102, India.Bioinformatics Centre and Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram 442-102, India.Datta Meghe Institute of Medical Sciences (Deemed University), Nagpur 440-022, India.Bioinformatics Centre and Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram 442-102, India.Department of Biotechnology, Ministry of Science and Technology, New Delhi 110-003, India.Advanced Centre for Treatment, Research and Education in Cancer, Khargar 410-210, India.Human papillomavirus (HPV) infection is the leading cause of cancer mortality among women worldwide. The molecular understanding of HPV proteins has significant connotation for understanding their intrusion in the host and designing novel protein vaccines and anti-viral agents, etc. Genomic, proteomic, structural, and disease-related information on HPV is available on the web; yet, with trivial annotations and more so, it is not well customized for data analysis, host-pathogen interaction, strain-disease association, drug designing, and sequence analysis, etc. We attempted to design an online reserve with comprehensive information on HPV for the end users desiring the same. The Human Papillomavirus Proteome Database (hpvPDB) domiciles proteomic and genomic information on 150 HPV strains sequenced to date. Simultaneous easy expandability and retrieval of the strain-specific data, with a provision for sequence analysis and exploration potential of predicted structures, and easy access for curation and annotation through a range of search options at one platform are a few of its important features. Affluent information in this reserve could be of help for researchers involved in structural virology, cancer research, drug discovery, and vaccine design.http://genominfo.org/upload/pdf/gni-11-289.pdfcomparative modelingDNA probesgenomeHPVneoplasmsproteome
spellingShingle Satish Kumar
Lingaraja Jena
Sangeeta Daf
Kanchan Mohod
Peyush Goyal
Ashok K. Varma
hpvPDB: An Online Proteome Reserve for Human Papillomavirus
Genomics & Informatics
comparative modeling
DNA probes
genome
HPV
neoplasms
proteome
title hpvPDB: An Online Proteome Reserve for Human Papillomavirus
title_full hpvPDB: An Online Proteome Reserve for Human Papillomavirus
title_fullStr hpvPDB: An Online Proteome Reserve for Human Papillomavirus
title_full_unstemmed hpvPDB: An Online Proteome Reserve for Human Papillomavirus
title_short hpvPDB: An Online Proteome Reserve for Human Papillomavirus
title_sort hpvpdb an online proteome reserve for human papillomavirus
topic comparative modeling
DNA probes
genome
HPV
neoplasms
proteome
url http://genominfo.org/upload/pdf/gni-11-289.pdf
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