Systemic DNA damage in Brazilian farmers exposed to pesticides
The chronic health effects of pesticides exposure include reproductive damage, neurological damage, hormonal dysfunction, and cancer; the genotoxic effects of pesticides are the primary factor contributing to carcinogenesis. To measure DNA damage, two techniques have stood out for risk an...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Academia.edu Journals
2025-03-01
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| Series: | Academia Molecular Biology and Genomics |
| Online Access: | https://www.academia.edu/128336793/Systemic_DNA_damage_in_Brazilian_farmers_exposed_to_pesticides |
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| Summary: | The chronic health effects of pesticides exposure include reproductive damage, neurological damage, hormonal dysfunction, and cancer; the genotoxic effects of pesticides are the primary factor contributing to carcinogenesis. To measure DNA damage, two techniques have stood out for risk analysis in exposed populations: the comet assay and the cytokinesis-blocked micronucleus (CBMN) technique. Therefore, we have conducted a review of published articles on DNA damage in Brazilian farmers exposed to pesticides, with the aim of finding out whether our farmers are at increased risk of health problems. The period covered by the studies was from Jan 2009 to Dec 2024. After undergoing a thorough selection, fourteen articles composed the final analysis, totaling 801 farmers and 708 controls. In the means comparison between the exposed and control groups, first a heterogeneity assessment was made, which indicated a strong heterogeneity (I2) both for the tails length (tl) means from the comet assay (I2 = 91.6%; p <0.001) and for the frequency of micronuclei (I2 = 92.8%; p <0.001), so we chose the random model of analysis. When comparing the means obtained in the comet assay, the absolute difference between the means (WMD) was 14.388, with p <0.001. Increased values of DNA damage measured by both CBMN and comet assays were observed in most studies included in this review, and we found higher DNA damage in Brazilian farmers compared with the controls by applying a meta-analysis on the results of the studied articles. |
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| ISSN: | 3064-9765 |