JAK/STAT signaling in hepatocellular carcinoma
Liver cancer is the second most lethal cancer in the world with limited treatment options. Hepatocellular carcinoma (HCC), which accounts for more than 80% of all liver cancers, has had increasing global incidence over the past few years. There is an urgent need for novel and better therapeutic inte...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis
2020-03-01
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| Series: | Hepatic Oncology |
| Subjects: | |
| Online Access: | https://www.futuremedicine.com/doi/10.2217/hep-2020-0001 |
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| _version_ | 1850152893792911360 |
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| author | Justin Jit Hin Tang Dexter Kai Hao Thng Jhin Jieh Lim Tan Boon Toh |
| author_facet | Justin Jit Hin Tang Dexter Kai Hao Thng Jhin Jieh Lim Tan Boon Toh |
| author_sort | Justin Jit Hin Tang |
| collection | DOAJ |
| description | Liver cancer is the second most lethal cancer in the world with limited treatment options. Hepatocellular carcinoma (HCC), which accounts for more than 80% of all liver cancers, has had increasing global incidence over the past few years. There is an urgent need for novel and better therapeutic intervention for HCC patients. The JAK/STAT signaling pathway plays a multitude of important biological functions in both normal and malignant cells. In a subset of HCC, JAK/STAT signaling is aberrantly activated, leading to dysregulation of downstream target genes that controls survival, angiogenesis, stemness, immune surveillance, invasion and metastasis. In this review, we will focus on the role of JAK/STAT signaling in HCC and discuss the current clinical status of several JAK/STAT inhibitors. |
| format | Article |
| id | doaj-art-555bc198a946489f89eef72f68a8c8ba |
| institution | OA Journals |
| issn | 2045-0923 2045-0931 |
| language | English |
| publishDate | 2020-03-01 |
| publisher | Taylor & Francis |
| record_format | Article |
| series | Hepatic Oncology |
| spelling | doaj-art-555bc198a946489f89eef72f68a8c8ba2025-08-20T02:25:51ZengTaylor & FrancisHepatic Oncology2045-09232045-09312020-03-017110.2217/hep-2020-0001JAK/STAT signaling in hepatocellular carcinomaJustin Jit Hin Tang0Dexter Kai Hao Thng1Jhin Jieh Lim2Tan Boon Toh31The N.1 Institute for Health (N.1), National University of Singapore, Singapore2Cancer Science Institute of Singapore, National University of Singapore, Singapore2Cancer Science Institute of Singapore, National University of Singapore, Singapore1The N.1 Institute for Health (N.1), National University of Singapore, SingaporeLiver cancer is the second most lethal cancer in the world with limited treatment options. Hepatocellular carcinoma (HCC), which accounts for more than 80% of all liver cancers, has had increasing global incidence over the past few years. There is an urgent need for novel and better therapeutic intervention for HCC patients. The JAK/STAT signaling pathway plays a multitude of important biological functions in both normal and malignant cells. In a subset of HCC, JAK/STAT signaling is aberrantly activated, leading to dysregulation of downstream target genes that controls survival, angiogenesis, stemness, immune surveillance, invasion and metastasis. In this review, we will focus on the role of JAK/STAT signaling in HCC and discuss the current clinical status of several JAK/STAT inhibitors.https://www.futuremedicine.com/doi/10.2217/hep-2020-0001hepatocarcinogenesishepatocellular carcinomaJAK/STAT signalingliver cancertargeted therapy |
| spellingShingle | Justin Jit Hin Tang Dexter Kai Hao Thng Jhin Jieh Lim Tan Boon Toh JAK/STAT signaling in hepatocellular carcinoma Hepatic Oncology hepatocarcinogenesis hepatocellular carcinoma JAK/STAT signaling liver cancer targeted therapy |
| title | JAK/STAT signaling in hepatocellular carcinoma |
| title_full | JAK/STAT signaling in hepatocellular carcinoma |
| title_fullStr | JAK/STAT signaling in hepatocellular carcinoma |
| title_full_unstemmed | JAK/STAT signaling in hepatocellular carcinoma |
| title_short | JAK/STAT signaling in hepatocellular carcinoma |
| title_sort | jak stat signaling in hepatocellular carcinoma |
| topic | hepatocarcinogenesis hepatocellular carcinoma JAK/STAT signaling liver cancer targeted therapy |
| url | https://www.futuremedicine.com/doi/10.2217/hep-2020-0001 |
| work_keys_str_mv | AT justinjithintang jakstatsignalinginhepatocellularcarcinoma AT dexterkaihaothng jakstatsignalinginhepatocellularcarcinoma AT jhinjiehlim jakstatsignalinginhepatocellularcarcinoma AT tanboontoh jakstatsignalinginhepatocellularcarcinoma |