Complement Diagnostics: Concepts, Indications, and Practical Guidelines
Aberrations in the complement system have been shown to be direct or indirect pathophysiological mechanisms in a number of diseases and pathological conditions such as autoimmune disease, infections, cancer, allogeneic and xenogeneic transplantation, and inflammation. Complement analyses have been p...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/962702 |
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| _version_ | 1832551947503140864 |
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| author | Bo Nilsson Kristina Nilsson Ekdahl |
| author_facet | Bo Nilsson Kristina Nilsson Ekdahl |
| author_sort | Bo Nilsson |
| collection | DOAJ |
| description | Aberrations in the complement system have been shown to be direct or indirect pathophysiological mechanisms in a number of diseases and pathological conditions such as autoimmune disease, infections, cancer, allogeneic and xenogeneic transplantation, and inflammation. Complement analyses have been performed on these conditions in both prospective and retrospective studies and significant differences have been found between groups of patients, but in many diseases, it has not been possible to make predictions for individual patients because of the lack of sensitivity and specificity of many of the assays used. The basic indications for serological diagnostic complement analysis today may be divided into three major categories: (a) acquired and inherited complement deficiencies; (b) disorders with complement activation; (c) inherited and acquired C1INH deficiencies. Here, we summarize indications, techniques, and interpretations for basic complement analyses and present an algorithm, which we follow in our routine laboratory. |
| format | Article |
| id | doaj-art-554c00c4d38d47c982ebb05278604680 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-554c00c4d38d47c982ebb052786046802025-02-03T05:59:53ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/962702962702Complement Diagnostics: Concepts, Indications, and Practical GuidelinesBo Nilsson0Kristina Nilsson Ekdahl1Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 751 85 Uppsala, SwedenDepartment of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 751 85 Uppsala, SwedenAberrations in the complement system have been shown to be direct or indirect pathophysiological mechanisms in a number of diseases and pathological conditions such as autoimmune disease, infections, cancer, allogeneic and xenogeneic transplantation, and inflammation. Complement analyses have been performed on these conditions in both prospective and retrospective studies and significant differences have been found between groups of patients, but in many diseases, it has not been possible to make predictions for individual patients because of the lack of sensitivity and specificity of many of the assays used. The basic indications for serological diagnostic complement analysis today may be divided into three major categories: (a) acquired and inherited complement deficiencies; (b) disorders with complement activation; (c) inherited and acquired C1INH deficiencies. Here, we summarize indications, techniques, and interpretations for basic complement analyses and present an algorithm, which we follow in our routine laboratory.http://dx.doi.org/10.1155/2012/962702 |
| spellingShingle | Bo Nilsson Kristina Nilsson Ekdahl Complement Diagnostics: Concepts, Indications, and Practical Guidelines Clinical and Developmental Immunology |
| title | Complement Diagnostics: Concepts, Indications, and Practical Guidelines |
| title_full | Complement Diagnostics: Concepts, Indications, and Practical Guidelines |
| title_fullStr | Complement Diagnostics: Concepts, Indications, and Practical Guidelines |
| title_full_unstemmed | Complement Diagnostics: Concepts, Indications, and Practical Guidelines |
| title_short | Complement Diagnostics: Concepts, Indications, and Practical Guidelines |
| title_sort | complement diagnostics concepts indications and practical guidelines |
| url | http://dx.doi.org/10.1155/2012/962702 |
| work_keys_str_mv | AT bonilsson complementdiagnosticsconceptsindicationsandpracticalguidelines AT kristinanilssonekdahl complementdiagnosticsconceptsindicationsandpracticalguidelines |