Nuclear Condensates of WW Domain‐Containing Adaptor With Coiled‐Coil Regulate Mitophagy via Alternative Splicing

Nuclear Condensates of WW Domain‐Containing Adaptor With Coiled‐Coil Regulate Mitophagy via Alternative Splicing

Abstract Biomolecular condensates segregate nuclei into discrete regions, facilitating the execution of distinct biological functions. Here, it is identified that the WW domain containing adaptor with coiled‐coil (WAC) is localized to nuclear speckles via its WW domain and plays a pivotal role in re...

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Main Authors: Jiahe Wang, Yi Fan, Guowen Luo, Liang Xiong, Lijie Wang, Zhuoxuan Wu, Jiayi Wang, Zhengying Peng, Clifford J Rosen, Kefeng Lu, Junjun Jing, Quan Yuan, Zhenwei Zhang, Chenchen Zhou
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
mitophagy
nuclear speckles
phase‐separated biomolecular condensates
pre‐mRNA splicing
snRNP
WAC
Online Access:https://doi.org/10.1002/advs.202406759
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