Surface‐Anchored Ticagrelor Gelatin Nanoparticles‐Platelets System for Enhanced Anti‐PD‐L1 Therapy Response and Boosted Chemotherapeutic Efficacy of Nanomedicines

Surface‐Anchored Ticagrelor Gelatin Nanoparticles‐Platelets System for Enhanced Anti‐PD‐L1 Therapy Response and Boosted Chemotherapeutic Efficacy of Nanomedicines

ABSTRACT The tumor microenvironment is characterized by immunosuppression and compromised intratumoral perfusion, which impairs the effectiveness of immune checkpoint inhibitors and nanomedicines. A significant challenge is the role of activated platelets, as they increase transfer‐mediated PD‐L1 ex...

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Bibliographic Details
Main Authors: Qi Lu, Hao Ye, Jian Zhao, Xiaoyuan Fan, Kaiyuan Wang, Zeyu Han, Tian Liu, Lili Du, Jiaxuan Song, Helin Wang, Haotian Zhang, Zhonggui He, Jin Sun
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Exploration
Subjects:
chemotherapy
immunotherapy
MMPs‐responsive release
platelet‐based delivery system
tumor‐associated platelets
Online Access:https://doi.org/10.1002/EXP.20240084
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