Predictors of Major Adverse Cardiovascular Events in Stable Patients After ST Elevation Myocardial Infarction
Background/aim: The aim of this study was to determine predictors of major adverse cardiovascular events, including MACE (mortality, non-fatal recurrent infarction, non-fatal stroke, and target vessel revascularization-TVR) in stable post-STEMI patients. Method: We analyzed STEMI patients without ca...
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MDPI AG
2025-05-01
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| Series: | Clinics and Practice |
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| Online Access: | https://www.mdpi.com/2039-7283/15/6/106 |
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| author | Lidija Savic Damjan Simic Ratko Lasica Gordana Krljanac Sanja Stankovic Igor Mrdovic Milika Asanin |
| author_facet | Lidija Savic Damjan Simic Ratko Lasica Gordana Krljanac Sanja Stankovic Igor Mrdovic Milika Asanin |
| author_sort | Lidija Savic |
| collection | DOAJ |
| description | Background/aim: The aim of this study was to determine predictors of major adverse cardiovascular events, including MACE (mortality, non-fatal recurrent infarction, non-fatal stroke, and target vessel revascularization-TVR) in stable post-STEMI patients. Method: We analyzed STEMI patients without cardiogenic shock at admission included in our STEMI Register. The patients were treated with primary PCI. The follow-up period was eight years. Results: From 1 December 2006 to 31 December 2016, a total of 3079 patients were included in the Register. In the first year, MACE was registered in 348 (11.3%) patients. The remaining patients were considered stable. They were included in further analysis. At eight years, the rates were as follows: MACE 3.9%, non-fatal recurrent infarction 2.1%, TVR 1.8%, non-fatal stroke 0.5%, and mortality 2.1%. Predictors for 8-year MACE were age >60 years (60–69 vs. <60 years HR 1.65; 70–79 vs. <60 years HR 1.82; ≥80 vs. <60 years HR 3.16), EF < 50% (EF 40–49% HR 2.38; EF < 40% HR 2.32), diabetes mellitus (HR 1.49), and 3-vessel coronary artery disease (HR 1.44). Conclusions: Four predictors identified stable post-STEMI patients who remained at a higher risk for the occurrence of MACE. Stable post-STEMI patients with one or more of these risk factors may require more aggressive secondary prevention measures or a personalized approach to improve their prognosis. |
| format | Article |
| id | doaj-art-553e8fde78bc41ef809567e85c56764d |
| institution | OA Journals |
| issn | 2039-7283 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Clinics and Practice |
| spelling | doaj-art-553e8fde78bc41ef809567e85c56764d2025-08-20T02:24:21ZengMDPI AGClinics and Practice2039-72832025-05-0115610610.3390/clinpract15060106Predictors of Major Adverse Cardiovascular Events in Stable Patients After ST Elevation Myocardial InfarctionLidija Savic0Damjan Simic1Ratko Lasica2Gordana Krljanac3Sanja Stankovic4Igor Mrdovic5Milika Asanin6Faculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaCardiology Intensive Care Unit & Cardiology Clinic, Emergency Hospital, University Clinical Center of Serbia, 11000 Belgrade, SerbiaFaculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaFaculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaCenter for Medical Biochemistry, Emergency Hospital, University Clinical Center of Serbia, 11000 Belgrade, SerbiaCardiology Intensive Care Unit & Cardiology Clinic, Emergency Hospital, University Clinical Center of Serbia, 11000 Belgrade, SerbiaFaculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaBackground/aim: The aim of this study was to determine predictors of major adverse cardiovascular events, including MACE (mortality, non-fatal recurrent infarction, non-fatal stroke, and target vessel revascularization-TVR) in stable post-STEMI patients. Method: We analyzed STEMI patients without cardiogenic shock at admission included in our STEMI Register. The patients were treated with primary PCI. The follow-up period was eight years. Results: From 1 December 2006 to 31 December 2016, a total of 3079 patients were included in the Register. In the first year, MACE was registered in 348 (11.3%) patients. The remaining patients were considered stable. They were included in further analysis. At eight years, the rates were as follows: MACE 3.9%, non-fatal recurrent infarction 2.1%, TVR 1.8%, non-fatal stroke 0.5%, and mortality 2.1%. Predictors for 8-year MACE were age >60 years (60–69 vs. <60 years HR 1.65; 70–79 vs. <60 years HR 1.82; ≥80 vs. <60 years HR 3.16), EF < 50% (EF 40–49% HR 2.38; EF < 40% HR 2.32), diabetes mellitus (HR 1.49), and 3-vessel coronary artery disease (HR 1.44). Conclusions: Four predictors identified stable post-STEMI patients who remained at a higher risk for the occurrence of MACE. Stable post-STEMI patients with one or more of these risk factors may require more aggressive secondary prevention measures or a personalized approach to improve their prognosis.https://www.mdpi.com/2039-7283/15/6/106stable post myocardial infarctionmajor adverse cardiovascular eventsprognosis |
| spellingShingle | Lidija Savic Damjan Simic Ratko Lasica Gordana Krljanac Sanja Stankovic Igor Mrdovic Milika Asanin Predictors of Major Adverse Cardiovascular Events in Stable Patients After ST Elevation Myocardial Infarction Clinics and Practice stable post myocardial infarction major adverse cardiovascular events prognosis |
| title | Predictors of Major Adverse Cardiovascular Events in Stable Patients After ST Elevation Myocardial Infarction |
| title_full | Predictors of Major Adverse Cardiovascular Events in Stable Patients After ST Elevation Myocardial Infarction |
| title_fullStr | Predictors of Major Adverse Cardiovascular Events in Stable Patients After ST Elevation Myocardial Infarction |
| title_full_unstemmed | Predictors of Major Adverse Cardiovascular Events in Stable Patients After ST Elevation Myocardial Infarction |
| title_short | Predictors of Major Adverse Cardiovascular Events in Stable Patients After ST Elevation Myocardial Infarction |
| title_sort | predictors of major adverse cardiovascular events in stable patients after st elevation myocardial infarction |
| topic | stable post myocardial infarction major adverse cardiovascular events prognosis |
| url | https://www.mdpi.com/2039-7283/15/6/106 |
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