Aspiration-Induced Acute Lung Injury: Experimental Morphological Study
Objective: to reveal early lung morphological changes after acidin-pepsin aspiration (a combination of hydrochloric acid and proteolytic enzyme). Material and methods. An experiment was made on 30 non-inbred albino male rats whose trachea acidin-pepsin solution (pH 1.2) was administered into. The ex...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2008-06-01
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| Series: | Общая реаниматология |
| Online Access: | https://www.reanimatology.com/rmt/article/view/742 |
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| author | A. M Golubev Yu. A. Gorodovikova V. V. Moroz Yu. V Marchenkov D. V. Sundukov |
| author_facet | A. M Golubev Yu. A. Gorodovikova V. V. Moroz Yu. V Marchenkov D. V. Sundukov |
| author_sort | A. M Golubev |
| collection | DOAJ |
| description | Objective: to reveal early lung morphological changes after acidin-pepsin aspiration (a combination of hydrochloric acid and proteolytic enzyme). Material and methods. An experiment was made on 30 non-inbred albino male rats whose trachea acidin-pepsin solution (pH 1.2) was administered into. The experiment lasted 1 to 24 hours. Lung histological specimens were stained with hematoxylin and eosin. Results. After an hour of surgery, all the animals developed interstitial edema, had the desquamated bronchial epithelium, segmented leukocytic infiltration of alveolar septa, hemorrhages, and sludges. Conclusion. Acidin-pepsin aspiration leads to the development of acute lung injury verified by morphological studies. Key words: aspiration, acute lung lesion. |
| format | Article |
| id | doaj-art-553a686de04045218df2d2d68e06977f |
| institution | Kabale University |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2008-06-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-553a686de04045218df2d2d68e06977f2025-08-20T03:43:43ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102008-06-014310.15360/1813-9779-2008-3-5742Aspiration-Induced Acute Lung Injury: Experimental Morphological StudyA. M GolubevYu. A. GorodovikovaV. V. MorozYu. V MarchenkovD. V. SundukovObjective: to reveal early lung morphological changes after acidin-pepsin aspiration (a combination of hydrochloric acid and proteolytic enzyme). Material and methods. An experiment was made on 30 non-inbred albino male rats whose trachea acidin-pepsin solution (pH 1.2) was administered into. The experiment lasted 1 to 24 hours. Lung histological specimens were stained with hematoxylin and eosin. Results. After an hour of surgery, all the animals developed interstitial edema, had the desquamated bronchial epithelium, segmented leukocytic infiltration of alveolar septa, hemorrhages, and sludges. Conclusion. Acidin-pepsin aspiration leads to the development of acute lung injury verified by morphological studies. Key words: aspiration, acute lung lesion.https://www.reanimatology.com/rmt/article/view/742 |
| spellingShingle | A. M Golubev Yu. A. Gorodovikova V. V. Moroz Yu. V Marchenkov D. V. Sundukov Aspiration-Induced Acute Lung Injury: Experimental Morphological Study Общая реаниматология |
| title | Aspiration-Induced Acute Lung Injury: Experimental Morphological Study |
| title_full | Aspiration-Induced Acute Lung Injury: Experimental Morphological Study |
| title_fullStr | Aspiration-Induced Acute Lung Injury: Experimental Morphological Study |
| title_full_unstemmed | Aspiration-Induced Acute Lung Injury: Experimental Morphological Study |
| title_short | Aspiration-Induced Acute Lung Injury: Experimental Morphological Study |
| title_sort | aspiration induced acute lung injury experimental morphological study |
| url | https://www.reanimatology.com/rmt/article/view/742 |
| work_keys_str_mv | AT amgolubev aspirationinducedacutelunginjuryexperimentalmorphologicalstudy AT yuagorodovikova aspirationinducedacutelunginjuryexperimentalmorphologicalstudy AT vvmoroz aspirationinducedacutelunginjuryexperimentalmorphologicalstudy AT yuvmarchenkov aspirationinducedacutelunginjuryexperimentalmorphologicalstudy AT dvsundukov aspirationinducedacutelunginjuryexperimentalmorphologicalstudy |