Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer’s disease: a multi-tracer PET study

Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer’s disease: a multi-tracer PET study

Abstract Background The pathological effects of amyloid β oligomers (Aβo) may be mediated through the metabotropic glutamate receptor subtype 5 (mGluR5), leading to synaptic loss in Alzheimer’s disease (AD). Positron emission tomography (PET) studies of mGluR5 using [18F]FPEB indicate a reduction of...

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Bibliographic Details
Main Authors: Elaheh Salardini, Ryan S. O’Dell, Em Tchorz, Nabeel B. Nabulsi, Yiyun Huang, Richard E. Carson, Christopher H. van Dyck, Adam P. Mecca
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
MGluR5 binding
Synaptic density
SV2A
PET
[18F]FPEB
Online Access:https://doi.org/10.1186/s13195-025-01739-1
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