RBM5/LUCA-15 — Tumour Suppression by Control of Apoptosis and the Cell Cycle?
The candidate tumour suppressor gene, LUCA-15, maps to the lung cancer tumour suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts, which have been shown to function as regulators of apoptosis, a fact that may have a major significance in tumour reg...
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| Format: | Article |
| Language: | English |
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Wiley
2002-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2002.859 |
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| _version_ | 1849412693725806592 |
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| author | Mirna Mourtada-Maarabouni Gwyn T. Williams |
| author_facet | Mirna Mourtada-Maarabouni Gwyn T. Williams |
| author_sort | Mirna Mourtada-Maarabouni |
| collection | DOAJ |
| description | The candidate tumour suppressor gene, LUCA-15, maps to the lung cancer tumour suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts, which have been shown to function as regulators of apoptosis, a fact that may have a major significance in tumour regulation. This review highlights evidence that implicates the LUCA-15 locus in the control of apoptosis and cell proliferation, and reports observations that significantly strengthen the case for tumour suppressor activity by this gene. |
| format | Article |
| id | doaj-art-552d6a1bef724d2fb4ce6579b3af3927 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2002-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-552d6a1bef724d2fb4ce6579b3af39272025-08-20T03:34:21ZengWileyThe Scientific World Journal1537-744X2002-01-0121885189010.1100/tsw.2002.859RBM5/LUCA-15 — Tumour Suppression by Control of Apoptosis and the Cell Cycle?Mirna Mourtada-Maarabouni0Gwyn T. Williams1School of Life Sciences, Keele University, Keele, Staffs, ST5 5BG, UKSchool of Life Sciences, Keele University, Keele, Staffs, ST5 5BG, UKThe candidate tumour suppressor gene, LUCA-15, maps to the lung cancer tumour suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts, which have been shown to function as regulators of apoptosis, a fact that may have a major significance in tumour regulation. This review highlights evidence that implicates the LUCA-15 locus in the control of apoptosis and cell proliferation, and reports observations that significantly strengthen the case for tumour suppressor activity by this gene.http://dx.doi.org/10.1100/tsw.2002.859 |
| spellingShingle | Mirna Mourtada-Maarabouni Gwyn T. Williams RBM5/LUCA-15 — Tumour Suppression by Control of Apoptosis and the Cell Cycle? The Scientific World Journal |
| title | RBM5/LUCA-15 — Tumour Suppression by Control of Apoptosis and the Cell Cycle? |
| title_full | RBM5/LUCA-15 — Tumour Suppression by Control of Apoptosis and the Cell Cycle? |
| title_fullStr | RBM5/LUCA-15 — Tumour Suppression by Control of Apoptosis and the Cell Cycle? |
| title_full_unstemmed | RBM5/LUCA-15 — Tumour Suppression by Control of Apoptosis and the Cell Cycle? |
| title_short | RBM5/LUCA-15 — Tumour Suppression by Control of Apoptosis and the Cell Cycle? |
| title_sort | rbm5 luca 15 tumour suppression by control of apoptosis and the cell cycle |
| url | http://dx.doi.org/10.1100/tsw.2002.859 |
| work_keys_str_mv | AT mirnamourtadamaarabouni rbm5luca15tumoursuppressionbycontrolofapoptosisandthecellcycle AT gwyntwilliams rbm5luca15tumoursuppressionbycontrolofapoptosisandthecellcycle |