TIGAR coordinates senescence-associated secretory phenotype via lysosome repositioning and α-tubulin deacetylation

TIGAR coordinates senescence-associated secretory phenotype via lysosome repositioning and α-tubulin deacetylation

Abstract TP53-induced glycolysis and apoptosis regulator (TIGAR) regulates redox homeostasis and provides the intermediates necessary for cell growth by reducing the glycolytic rate. During cellular senescence, cells undergo metabolic rewiring towards the glycolytic pathway, along with the developme...

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Main Authors: Hae Yun Nam, Seung-Ho Park, Geun-Hee Lee, Eun-Young Kim, SangEun Lee, Hyo Won Chang, Eun-Ju Chang, Kyung-Chul Choi, Seong Who Kim
Format: Article
Language:English
Published: Nature Publishing Group 2024-12-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-024-01362-4
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