Association Between a New Model of Insulin Sensitivity and Hypertension in Patients With Type 2 Diabetes: A Cross‐Sectional Study
ABSTRACT Type 2 diabetes (T2D) and hypertension often coexist, and insulin resistance (IR) plays an important role in their pathological progression. An increasing number of studies have focused on the relationship between different IR indices and hypertension. A natural log transformation of the gl...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-02-01
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| Series: | The Journal of Clinical Hypertension |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jch.70008 |
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| Summary: | ABSTRACT Type 2 diabetes (T2D) and hypertension often coexist, and insulin resistance (IR) plays an important role in their pathological progression. An increasing number of studies have focused on the relationship between different IR indices and hypertension. A natural log transformation of the glucose disposal rate (loge GDR) has been proposed as a new model for insulin sensitivity in patients with T2D. The study aimed to explore the relationship between loge GDR and hypertension in T2D patients. This cross‐sectional study included 1544 Chinese T2D patients. Clinical and biochemical characteristics were collected. The loge GDR was calculated based on triglycerides, urinary albumin to creatinine ratio, gamma‐glutamyl transferase, and body mass index. Patients were categorized into hypertension and nonhypertension groups stratified by gender. Among both females and males, compared with the nonhypertension group, the level of loge GDR was significantly decreased in the hypertension group (both p < 0.001). As the loge GDR increased, the levels of systolic and diastolic blood pressure, and the prevalence of hypertension were obviously increased (all p < 0.001). Univariate analysis displayed that loge GDR was negatively related to hypertension (correlation coefficient: −0.243, p < 0.001 in females; correlation coefficient: −0.181, p < 0.001 in males). Furthermore, the logistic regression analysis showed that loge GDR was independently associated with hypertension (OR: 0.456; 95% CI: 0.224–0.927 in females; OR: 0.544; 95% CI: 0.314–0.941 in males). This study revealed that loge GDR was closely related to hypertension, which might help monitor and manage hypertension in T2D patients. |
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| ISSN: | 1524-6175 1751-7176 |