Chronic lower limb wounds evoke systemic response of the lymphatic (immune) system
Wound healing should not be considered as a process limited only to the damaged tissues. It is always accompanied by an intensive local immune response and in advanced stages, the systemic lymphatic (immune) structure. In this review we present evidence from our own studies as well as pertinent lite...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical and Scientific Publishers Pvt. Ltd.
2012-05-01
|
| Series: | Indian Journal of Plastic Surgery |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/0970-0358.101289 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849412693271773184 |
|---|---|
| author | W. L. Olszewski P. Jain M. Zaleska E. Stelmach E. Swoboda |
| author_facet | W. L. Olszewski P. Jain M. Zaleska E. Stelmach E. Swoboda |
| author_sort | W. L. Olszewski |
| collection | DOAJ |
| description | Wound healing should not be considered as a process limited only to the damaged tissues. It is always accompanied by an intensive local immune response and in advanced stages, the systemic lymphatic (immune) structure. In this review we present evidence from our own studies as well as pertinent literature on the role of skin and subcutaneous tissue lymphatics at the wound site and of transport of antigens along with collecting afferent lymphatics to the lymph nodes. We also speculate the role of lymph nodes in raising cohorts of bacterial and own tissue antigen-specific lymphocytes and their participation in healing and not infrequently evoking uncontrolled chronic immune reaction causing a delay of healing. It is also speculated as to why there is a rapid response of lymph node cells to microbial antigens and tolerance to damaged-tissue-derived antigens occurs |
| format | Article |
| id | doaj-art-5527dfe81f184e1daf7e84a164be7837 |
| institution | Kabale University |
| issn | 0970-0358 1998-376X |
| language | English |
| publishDate | 2012-05-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Plastic Surgery |
| spelling | doaj-art-5527dfe81f184e1daf7e84a164be78372025-08-20T03:34:21ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Plastic Surgery0970-03581998-376X2012-05-01450225526010.4103/0970-0358.101289Chronic lower limb wounds evoke systemic response of the lymphatic (immune) systemW. L. Olszewski0P. Jain1M. Zaleska2E. Stelmach3E. Swoboda4Department of Surgical Research, Medical Research Center, Polish Academy of Sciences, Warsaw, PolandDepartment of Plastic Surgery, Benaras Hindu University, Institute of Medical Sciences, Varanasi, IndiaDepartment of Surgical Research, Medical Research Center, Polish Academy of Sciences, Warsaw, PolandDepartment of Microbiology, Warsaw Medical University, Warsaw, PolandDepartment of Microbiology, Warsaw Medical University, Warsaw, PolandWound healing should not be considered as a process limited only to the damaged tissues. It is always accompanied by an intensive local immune response and in advanced stages, the systemic lymphatic (immune) structure. In this review we present evidence from our own studies as well as pertinent literature on the role of skin and subcutaneous tissue lymphatics at the wound site and of transport of antigens along with collecting afferent lymphatics to the lymph nodes. We also speculate the role of lymph nodes in raising cohorts of bacterial and own tissue antigen-specific lymphocytes and their participation in healing and not infrequently evoking uncontrolled chronic immune reaction causing a delay of healing. It is also speculated as to why there is a rapid response of lymph node cells to microbial antigens and tolerance to damaged-tissue-derived antigens occurshttp://www.thieme-connect.de/DOI/DOI?10.4103/0970-0358.101289healingimmunitywound |
| spellingShingle | W. L. Olszewski P. Jain M. Zaleska E. Stelmach E. Swoboda Chronic lower limb wounds evoke systemic response of the lymphatic (immune) system Indian Journal of Plastic Surgery healing immunity wound |
| title | Chronic lower limb wounds evoke systemic response of the lymphatic (immune) system |
| title_full | Chronic lower limb wounds evoke systemic response of the lymphatic (immune) system |
| title_fullStr | Chronic lower limb wounds evoke systemic response of the lymphatic (immune) system |
| title_full_unstemmed | Chronic lower limb wounds evoke systemic response of the lymphatic (immune) system |
| title_short | Chronic lower limb wounds evoke systemic response of the lymphatic (immune) system |
| title_sort | chronic lower limb wounds evoke systemic response of the lymphatic immune system |
| topic | healing immunity wound |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/0970-0358.101289 |
| work_keys_str_mv | AT wlolszewski chroniclowerlimbwoundsevokesystemicresponseofthelymphaticimmunesystem AT pjain chroniclowerlimbwoundsevokesystemicresponseofthelymphaticimmunesystem AT mzaleska chroniclowerlimbwoundsevokesystemicresponseofthelymphaticimmunesystem AT estelmach chroniclowerlimbwoundsevokesystemicresponseofthelymphaticimmunesystem AT eswoboda chroniclowerlimbwoundsevokesystemicresponseofthelymphaticimmunesystem |