Inhibitory effect of 1,4,5,6-tetrahydroxy-7,8-diprenylxanthone against NSCLC with L858R/T790M/C797S mutant EGFR

Inhibitory effect of 1,4,5,6-tetrahydroxy-7,8-diprenylxanthone against NSCLC with L858R/T790M/C797S mutant EGFR

Abstract Epidermal growth factor receptor (EGFR)-activating mutations are critical factors in the development of EGFR-driven non-small-cell lung cancer (NSCLC), and molecular targeted therapies have focused on inhibiting these mutations. EGFR tyrosine kinase inhibitors (TKIs) have remarkable inhibit...

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Bibliographic Details
Main Authors: Jing Wang, Yuna Wang, Shuanggou Zhang, Yana Qu, Ruohan Zhang, Xuanjun Wang, Jun Sheng, Peiyuan Sun
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
NSCLC
EGFR L858R/T790M/C797S mutation
1,4,5,6-tetrahydroxy-7,8-diprenylxanthone
Osimertinib resistance
Cell viability
Online Access:https://doi.org/10.1038/s41598-024-78146-3
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