Autoimmunity against cytokines: Double strike in autoimmune disease, a historical perspective
Autoimmune responses are characterized by the development of antibodies and the activation of T lymphocytes against self-antigens. This leads to an effector immune response against tissues expressing antigens, which are later recognized by the host immune system. Host antigens attacked by antibodies...
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| Format: | Article |
| Language: | English |
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Instituto Nacional de Salud
2024-12-01
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| Series: | Biomédica: revista del Instituto Nacional de Salud |
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| Online Access: | https://revistabiomedica.org/index.php/biomedica/article/view/7570 |
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| author | Iván Insignares Luis E. Rodríguez Óscar Correa-Jiménez Alberto Alfaro-Murillo Laura Rincón-Arenas Andrés Sánchez Marlon Múnera |
| author_facet | Iván Insignares Luis E. Rodríguez Óscar Correa-Jiménez Alberto Alfaro-Murillo Laura Rincón-Arenas Andrés Sánchez Marlon Múnera |
| author_sort | Iván Insignares |
| collection | DOAJ |
| description | Autoimmune responses are characterized by the development of antibodies and the activation of T lymphocytes against self-antigens. This leads to an effector immune
response against tissues expressing antigens, which are later recognized by the host immune system.
Host antigens attacked by antibodies are called “autoantigens” and are of different kinds, including receptors, enzymes, and channel proteins. The autoimmune response is potentiated by cytokines that mediate the activation of Th1, Th2, or Th17 lymphocytes.
The released cytokines can also be recognized as autoantigens, meaning they can be targets of the autoimmune response. The effects of autoimmunity on cytokines or their receptors are diverse, and the mechanisms of this type of autoimmune response are discussed in this review. |
| format | Article |
| id | doaj-art-551e452ca44b4b668694ce0f2fb96a58 |
| institution | Kabale University |
| issn | 0120-4157 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Instituto Nacional de Salud |
| record_format | Article |
| series | Biomédica: revista del Instituto Nacional de Salud |
| spelling | doaj-art-551e452ca44b4b668694ce0f2fb96a582025-01-21T18:56:10ZengInstituto Nacional de SaludBiomédica: revista del Instituto Nacional de Salud0120-41572024-12-0144Sp. 220921910.7705/biomedica.75709025Autoimmunity against cytokines: Double strike in autoimmune disease, a historical perspectiveIván Insignares0https://orcid.org/0000-0002-9922-3671Luis E. Rodríguez1https://orcid.org/0009-0002-3924-0215Óscar Correa-Jiménez2https://orcid.org/0000-0001-6007-2821Alberto Alfaro-Murillo3https://orcid.org/0000-0002-0770-3943Laura Rincón-Arenas4https://orcid.org/0009-0000-1758-790XAndrés Sánchez5https://orcid.org/0000-0001-7460-3427Marlon Múnera6https://orcid.org/0000-0003-3428-0541Facultad de Ciencias de la Salud, Corporación Universitaria Rafael Núñez, Cartagena, ColombiaCentros Médicos Colsanitas, Bogotá, D. C., ColombiaGrupo de Investigación en Neumología e Inmunología en Pediatría, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, D. C., ColombiaDivisión de Inmunología, Departamento de Medicina Interna, Hospital San Juan de Dios, Caja Costarricense de Seguro Social, San José, Costa RicaUnidad de Alergias e Inmunología, Cayre IPS, Bogotá, D. C. ColombiaGrupo de Investigación Nuñista de Medicina – GINUMED, Facultad de Ciencias de la Salud,Grupo de Investigación Nuñista de Medicina – GINUMED, Facultad de Ciencias de la Salud, Corporación Universitaria Rafael Núñez, Cartagena, ColombiaAutoimmune responses are characterized by the development of antibodies and the activation of T lymphocytes against self-antigens. This leads to an effector immune response against tissues expressing antigens, which are later recognized by the host immune system. Host antigens attacked by antibodies are called “autoantigens” and are of different kinds, including receptors, enzymes, and channel proteins. The autoimmune response is potentiated by cytokines that mediate the activation of Th1, Th2, or Th17 lymphocytes. The released cytokines can also be recognized as autoantigens, meaning they can be targets of the autoimmune response. The effects of autoimmunity on cytokines or their receptors are diverse, and the mechanisms of this type of autoimmune response are discussed in this review.https://revistabiomedica.org/index.php/biomedica/article/view/7570autoimmunitycytokinesautoantigensautoantibodies |
| spellingShingle | Iván Insignares Luis E. Rodríguez Óscar Correa-Jiménez Alberto Alfaro-Murillo Laura Rincón-Arenas Andrés Sánchez Marlon Múnera Autoimmunity against cytokines: Double strike in autoimmune disease, a historical perspective Biomédica: revista del Instituto Nacional de Salud autoimmunity cytokines autoantigens autoantibodies |
| title | Autoimmunity against cytokines: Double strike in autoimmune disease, a historical perspective |
| title_full | Autoimmunity against cytokines: Double strike in autoimmune disease, a historical perspective |
| title_fullStr | Autoimmunity against cytokines: Double strike in autoimmune disease, a historical perspective |
| title_full_unstemmed | Autoimmunity against cytokines: Double strike in autoimmune disease, a historical perspective |
| title_short | Autoimmunity against cytokines: Double strike in autoimmune disease, a historical perspective |
| title_sort | autoimmunity against cytokines double strike in autoimmune disease a historical perspective |
| topic | autoimmunity cytokines autoantigens autoantibodies |
| url | https://revistabiomedica.org/index.php/biomedica/article/view/7570 |
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