Comprehensive immune profiling and predictive modelling of paediatric acute hepatitis of unknown aetiology from a Spanish cohort

Comprehensive immune profiling and predictive modelling of paediatric acute hepatitis of unknown aetiology from a Spanish cohort

IntroductionPaediatric acute hepatitis of unknown aetiology (PAHUA) has emerged as a global health concern, yet its cause remains unidentified. This study characterises the clinical and immunological profiles of PAHUA to identify reliable immune biomarkers for accurate diagnosis.MethodsSamples from...

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Main Authors: Roberto Lozano-Rodríguez, Loreto Hierro, María José Quiles, Alejandro Pascual-Iglesias, Verónica Terrón-Arcos, Gema Muñoz-Bartolo, Esteban Frauca, Francisco J. Cueto, Cristina Calvo, Laura Córdoba-García, Jesús Fernández-Felipe, Laura Hurtado-Navarro, Julia del Prado-Montero, Gonzalo Sáenz de Santa María-Diez, Daniel Arvelo-Rosario, Paloma Jara, Carlos del Fresno, Eduardo López-Collazo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
hepatitis
unknown aetiology
biomarker
Gal-9
sTim-3
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1599982/full
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