Impact of HIV on HPV-related cancers in men who have sex with men: a review
Co-infection with human immunodeficiency virus (HIV) significantly increases the incidence of human papillomavirus (HPV) infection and HPV-related cancers among men who have sex with men (MSM). Conversely, HPV infection can also influence HIV acquisition rates. HIV-induced immune suppression may aff...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1428491/full |
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| author | Zixuan Zhang Zixuan Zhang Yuying Xing Yuying Xing Tingdan Gong Wanlin Li Siwei Zhang Lanlan Wei |
| author_facet | Zixuan Zhang Zixuan Zhang Yuying Xing Yuying Xing Tingdan Gong Wanlin Li Siwei Zhang Lanlan Wei |
| author_sort | Zixuan Zhang |
| collection | DOAJ |
| description | Co-infection with human immunodeficiency virus (HIV) significantly increases the incidence of human papillomavirus (HPV) infection and HPV-related cancers among men who have sex with men (MSM). Conversely, HPV infection can also influence HIV acquisition rates. HIV-induced immune suppression may affect chromosomal stability, gene expression, protein function and other molecular components in MSM with HPV-related cancers. Additionally, HIV infection also alters cellular mechanisms by compromising immune responses and epithelial integrity. In this review, we reviewed the influence of HIV on specific HPV-related cancers in MSM, including oropharyngeal squamous cell carcinoma, penile cancer, and anal cancer. We integrated epidemiological data from the past five years and discussed diagnosis and treatment strategies. Overall, our review offers crucial insights into the underlying molecular and cellular mechanisms of these co-infection MSM patients. Our review aims to assist future research in developing effective treatment strategies for MSM with HIV/HPV co-infection. |
| format | Article |
| id | doaj-art-551b3960e2374abd8f4c61e993a83f5b |
| institution | Kabale University |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-551b3960e2374abd8f4c61e993a83f5b2025-01-20T05:23:44ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-01-011410.3389/fcimb.2024.14284911428491Impact of HIV on HPV-related cancers in men who have sex with men: a reviewZixuan Zhang0Zixuan Zhang1Yuying Xing2Yuying Xing3Tingdan Gong4Wanlin Li5Siwei Zhang6Lanlan Wei7National Clinical Research Center for Infectious Diseases, The Third People’s Hospital of Shenzhen, The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, ChinaSchool of Medicine, Southern University of Science and Technology, Shenzhen, ChinaNational Clinical Research Center for Infectious Diseases, The Third People’s Hospital of Shenzhen, The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, ChinaSchool of Medicine, Southern University of Science and Technology, Shenzhen, ChinaNational Clinical Research Center for Infectious Diseases, The Third People’s Hospital of Shenzhen, The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, ChinaNational Clinical Research Center for Infectious Diseases, The Third People’s Hospital of Shenzhen, The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, ChinaNational Clinical Research Center for Infectious Diseases, The Third People’s Hospital of Shenzhen, The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, ChinaNational Clinical Research Center for Infectious Diseases, The Third People’s Hospital of Shenzhen, The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, ChinaCo-infection with human immunodeficiency virus (HIV) significantly increases the incidence of human papillomavirus (HPV) infection and HPV-related cancers among men who have sex with men (MSM). Conversely, HPV infection can also influence HIV acquisition rates. HIV-induced immune suppression may affect chromosomal stability, gene expression, protein function and other molecular components in MSM with HPV-related cancers. Additionally, HIV infection also alters cellular mechanisms by compromising immune responses and epithelial integrity. In this review, we reviewed the influence of HIV on specific HPV-related cancers in MSM, including oropharyngeal squamous cell carcinoma, penile cancer, and anal cancer. We integrated epidemiological data from the past five years and discussed diagnosis and treatment strategies. Overall, our review offers crucial insights into the underlying molecular and cellular mechanisms of these co-infection MSM patients. Our review aims to assist future research in developing effective treatment strategies for MSM with HIV/HPV co-infection.https://www.frontiersin.org/articles/10.3389/fcimb.2024.1428491/fullhuman papillomavirushuman immunodeficiency virusMSMco-infectioncancer |
| spellingShingle | Zixuan Zhang Zixuan Zhang Yuying Xing Yuying Xing Tingdan Gong Wanlin Li Siwei Zhang Lanlan Wei Impact of HIV on HPV-related cancers in men who have sex with men: a review Frontiers in Cellular and Infection Microbiology human papillomavirus human immunodeficiency virus MSM co-infection cancer |
| title | Impact of HIV on HPV-related cancers in men who have sex with men: a review |
| title_full | Impact of HIV on HPV-related cancers in men who have sex with men: a review |
| title_fullStr | Impact of HIV on HPV-related cancers in men who have sex with men: a review |
| title_full_unstemmed | Impact of HIV on HPV-related cancers in men who have sex with men: a review |
| title_short | Impact of HIV on HPV-related cancers in men who have sex with men: a review |
| title_sort | impact of hiv on hpv related cancers in men who have sex with men a review |
| topic | human papillomavirus human immunodeficiency virus MSM co-infection cancer |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1428491/full |
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