Dietary Sucrose Determines Stress Resistance, Oxidative Damages, and Antioxidant Defense System in Drosophila
Varied nutritional interventions affect lifespan and metabolic health. Abundant experimental evidence indicates that the carbohydrate restriction in the diet induces changes to support long-lived phenotypes. Reactive oxygen species (ROS) are among the main mechanisms that mediate the effect of nutri...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.1155/2022/7262342 |
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| _version_ | 1849412689232658432 |
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| author | Olha Strilbytska Tetiana Strutynska Uliana Semaniuk Nadia Burdyliyk Volodymyr Bubalo Oleh Lushchak |
| author_facet | Olha Strilbytska Tetiana Strutynska Uliana Semaniuk Nadia Burdyliyk Volodymyr Bubalo Oleh Lushchak |
| author_sort | Olha Strilbytska |
| collection | DOAJ |
| description | Varied nutritional interventions affect lifespan and metabolic health. Abundant experimental evidence indicates that the carbohydrate restriction in the diet induces changes to support long-lived phenotypes. Reactive oxygen species (ROS) are among the main mechanisms that mediate the effect of nutrient consumption on the aging process. Here, we tested the influence of sucrose concentration in the diet on stress resistance, antioxidant defense systems, and oxidative stress markers in D. melanogaster. We found that high sucrose concentration in the fly medium leads to enhanced resistance to starvation, oxidative, heat, and cold stresses. However, flies that were raised on low sucrose food displayed increased levels of low-molecular-mass thiols, lipid peroxides in females, and higher activity of antioxidant enzymes, indicating that the consumption of a low carbohydrate diet could induce oxidative stress in the fruit fly. We found that the consumption of sucrose-enriched diet increased protein carbonyl level, which may indicate about the activation of glycation processes. The results highlight a strong dependence of oxidative metabolism in D. melanogaster from dietary carbohydrates. |
| format | Article |
| id | doaj-art-551943b2029d42e08cc86bc8796b1400 |
| institution | Kabale University |
| issn | 2090-908X |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-551943b2029d42e08cc86bc8796b14002025-08-20T03:34:21ZengWileyScientifica2090-908X2022-01-01202210.1155/2022/7262342Dietary Sucrose Determines Stress Resistance, Oxidative Damages, and Antioxidant Defense System in DrosophilaOlha Strilbytska0Tetiana Strutynska1Uliana Semaniuk2Nadia Burdyliyk3Volodymyr Bubalo4Oleh Lushchak5Department of Biochemistry and BiotechnologyDepartment of Biochemistry and BiotechnologyDepartment of Biochemistry and BiotechnologyDepartment of Biochemistry and BiotechnologyLaboratory of Experimental Toxicology and MutagenesisDepartment of Biochemistry and BiotechnologyVaried nutritional interventions affect lifespan and metabolic health. Abundant experimental evidence indicates that the carbohydrate restriction in the diet induces changes to support long-lived phenotypes. Reactive oxygen species (ROS) are among the main mechanisms that mediate the effect of nutrient consumption on the aging process. Here, we tested the influence of sucrose concentration in the diet on stress resistance, antioxidant defense systems, and oxidative stress markers in D. melanogaster. We found that high sucrose concentration in the fly medium leads to enhanced resistance to starvation, oxidative, heat, and cold stresses. However, flies that were raised on low sucrose food displayed increased levels of low-molecular-mass thiols, lipid peroxides in females, and higher activity of antioxidant enzymes, indicating that the consumption of a low carbohydrate diet could induce oxidative stress in the fruit fly. We found that the consumption of sucrose-enriched diet increased protein carbonyl level, which may indicate about the activation of glycation processes. The results highlight a strong dependence of oxidative metabolism in D. melanogaster from dietary carbohydrates.http://dx.doi.org/10.1155/2022/7262342 |
| spellingShingle | Olha Strilbytska Tetiana Strutynska Uliana Semaniuk Nadia Burdyliyk Volodymyr Bubalo Oleh Lushchak Dietary Sucrose Determines Stress Resistance, Oxidative Damages, and Antioxidant Defense System in Drosophila Scientifica |
| title | Dietary Sucrose Determines Stress Resistance, Oxidative Damages, and Antioxidant Defense System in Drosophila |
| title_full | Dietary Sucrose Determines Stress Resistance, Oxidative Damages, and Antioxidant Defense System in Drosophila |
| title_fullStr | Dietary Sucrose Determines Stress Resistance, Oxidative Damages, and Antioxidant Defense System in Drosophila |
| title_full_unstemmed | Dietary Sucrose Determines Stress Resistance, Oxidative Damages, and Antioxidant Defense System in Drosophila |
| title_short | Dietary Sucrose Determines Stress Resistance, Oxidative Damages, and Antioxidant Defense System in Drosophila |
| title_sort | dietary sucrose determines stress resistance oxidative damages and antioxidant defense system in drosophila |
| url | http://dx.doi.org/10.1155/2022/7262342 |
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