A blockade of leukotriene-mediated Alox5 function provides a new strategy for the treatment of <i>JAK2</i>V617F-induced polycythemia vera

A blockade of leukotriene-mediated Alox5 function provides a new strategy for the treatment of <i>JAK2</i>V617F-induced polycythemia vera

Polycythemia vera (PV) is a hematopoietic stem cell disorder characterized by JAK2V617F, a mutation that gives rise to erythrocytosis. Our previous studies have shown that arachidonate 5-lipoxygenase (Alox5) is a critical driver in PV and the inhibition of the Alox5 pathway attenuates JAK2V617F-ind...

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Bibliographic Details
Main Authors: Yi Shan, Ngoc DeSouza, Noah Littman, Qiang Qiu, Kathy Nguyen, Yehua Yu, Golam Mohi, Shaoguang Li
Format: Article
Language:English
Published: Ferrata Storti Foundation 2025-06-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/12091
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