Evidence on the Heroin-Mediated Impairment of the Oxidative Status of Erythrocytes
Away from hemorheological properties, the effect of heroin addiction on erythrocytes is poorly investigated. This study aimed to investigate the oxidative impacts of heroin administration on erythrocytes. Study subjects included chronic intravenous heroin addicts and control subjects. Hematological...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2022/3996051 |
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| author | Mohammad A. Bani-Ahmad Ayman G. Mustafa Abdelraheem A. Bani Ahmad Islam E. Alkhazali Ahmad A. Rahim |
| author_facet | Mohammad A. Bani-Ahmad Ayman G. Mustafa Abdelraheem A. Bani Ahmad Islam E. Alkhazali Ahmad A. Rahim |
| author_sort | Mohammad A. Bani-Ahmad |
| collection | DOAJ |
| description | Away from hemorheological properties, the effect of heroin addiction on erythrocytes is poorly investigated. This study aimed to investigate the oxidative impacts of heroin administration on erythrocytes. Study subjects included chronic intravenous heroin addicts and control subjects. Hematological analysis and redox parameters were measured, including serum concentration of methemoglobin ([MethHb]), serum glutathione peroxidase-1 ([GPX-1]), serum glutathione peroxidase (GPX) activity, erythrocytic protein carbonyl content, and oxidized to reduced glutathione (GSSG/GSH) ratio. Hematological analysis revealed that addicts had a significantly higher red cell distribution width, consistent with the mild anisocytosis and poikilocytosis of erythrocytes. As compared to control subjects, significantly higher levels of serum [Met-Hb], [GPX-1], and GPX activity (p<0.001) were reported among addicted subjects. A significant association between [MetHb] and GPX activity was observed with r = 0.764 (p<0.001). Furthermore, significantly higher erythrocytic protein carbonyl contents and GSSG/GSH ratio were evident among heroin addicts (p<0.005) that were significantly associated with r = 0.429 (p=0.01). Results demonstrate preliminary evidence that heroin addiction is implicated in impaired redox status of erythrocytes. Considering the pharmacokinetics of heroin, erythrocytic antioxidant mechanisms, and turnover rate, further investigation is required to evaluate the extent and clinical outcomes, especially upon over-dose administration. |
| format | Article |
| id | doaj-art-5505f4fa3da84e42b672a6b11563da21 |
| institution | Kabale University |
| issn | 1687-8205 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-5505f4fa3da84e42b672a6b11563da212025-02-03T05:57:24ZengWileyJournal of Toxicology1687-82052022-01-01202210.1155/2022/3996051Evidence on the Heroin-Mediated Impairment of the Oxidative Status of ErythrocytesMohammad A. Bani-Ahmad0Ayman G. Mustafa1Abdelraheem A. Bani Ahmad2Islam E. Alkhazali3Ahmad A. Rahim4Department of Medical Laboratory ScienceDepartment of Basic Medical SciencesDepartment of Medical Laboratory ScienceDepartment of Medical Laboratory ScienceDepartment of Medical Laboratory ScienceAway from hemorheological properties, the effect of heroin addiction on erythrocytes is poorly investigated. This study aimed to investigate the oxidative impacts of heroin administration on erythrocytes. Study subjects included chronic intravenous heroin addicts and control subjects. Hematological analysis and redox parameters were measured, including serum concentration of methemoglobin ([MethHb]), serum glutathione peroxidase-1 ([GPX-1]), serum glutathione peroxidase (GPX) activity, erythrocytic protein carbonyl content, and oxidized to reduced glutathione (GSSG/GSH) ratio. Hematological analysis revealed that addicts had a significantly higher red cell distribution width, consistent with the mild anisocytosis and poikilocytosis of erythrocytes. As compared to control subjects, significantly higher levels of serum [Met-Hb], [GPX-1], and GPX activity (p<0.001) were reported among addicted subjects. A significant association between [MetHb] and GPX activity was observed with r = 0.764 (p<0.001). Furthermore, significantly higher erythrocytic protein carbonyl contents and GSSG/GSH ratio were evident among heroin addicts (p<0.005) that were significantly associated with r = 0.429 (p=0.01). Results demonstrate preliminary evidence that heroin addiction is implicated in impaired redox status of erythrocytes. Considering the pharmacokinetics of heroin, erythrocytic antioxidant mechanisms, and turnover rate, further investigation is required to evaluate the extent and clinical outcomes, especially upon over-dose administration.http://dx.doi.org/10.1155/2022/3996051 |
| spellingShingle | Mohammad A. Bani-Ahmad Ayman G. Mustafa Abdelraheem A. Bani Ahmad Islam E. Alkhazali Ahmad A. Rahim Evidence on the Heroin-Mediated Impairment of the Oxidative Status of Erythrocytes Journal of Toxicology |
| title | Evidence on the Heroin-Mediated Impairment of the Oxidative Status of Erythrocytes |
| title_full | Evidence on the Heroin-Mediated Impairment of the Oxidative Status of Erythrocytes |
| title_fullStr | Evidence on the Heroin-Mediated Impairment of the Oxidative Status of Erythrocytes |
| title_full_unstemmed | Evidence on the Heroin-Mediated Impairment of the Oxidative Status of Erythrocytes |
| title_short | Evidence on the Heroin-Mediated Impairment of the Oxidative Status of Erythrocytes |
| title_sort | evidence on the heroin mediated impairment of the oxidative status of erythrocytes |
| url | http://dx.doi.org/10.1155/2022/3996051 |
| work_keys_str_mv | AT mohammadabaniahmad evidenceontheheroinmediatedimpairmentoftheoxidativestatusoferythrocytes AT aymangmustafa evidenceontheheroinmediatedimpairmentoftheoxidativestatusoferythrocytes AT abdelraheemabaniahmad evidenceontheheroinmediatedimpairmentoftheoxidativestatusoferythrocytes AT islamealkhazali evidenceontheheroinmediatedimpairmentoftheoxidativestatusoferythrocytes AT ahmadarahim evidenceontheheroinmediatedimpairmentoftheoxidativestatusoferythrocytes |