Altered cortical swallowing processing in patients with functional dysphagia: a preliminary study.
<h4>Objective</h4>Current neuroimaging research on functional disturbances provides growing evidence for objective neuronal correlates of allegedly psychogenic symptoms, thereby shifting the disease concept from a psychological towards a neurobiological model. Functional dysphagia is suc...
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089665&type=printable |
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| author | Sonja Suntrup Inga Teismann Andreas Wollbrink Tobias Warnecke Martin Winkels Christo Pantev Rainer Dziewas |
| author_facet | Sonja Suntrup Inga Teismann Andreas Wollbrink Tobias Warnecke Martin Winkels Christo Pantev Rainer Dziewas |
| author_sort | Sonja Suntrup |
| collection | DOAJ |
| description | <h4>Objective</h4>Current neuroimaging research on functional disturbances provides growing evidence for objective neuronal correlates of allegedly psychogenic symptoms, thereby shifting the disease concept from a psychological towards a neurobiological model. Functional dysphagia is such a rare condition, whose pathogenetic mechanism is largely unknown. In the absence of any organic reason for a patient's persistent swallowing complaints, sensorimotor processing abnormalities involving central neural pathways constitute a potential etiology.<h4>Methods</h4>In this pilot study we measured cortical swallow-related activation in 5 patients diagnosed with functional dysphagia and a matched group of healthy subjects applying magnetoencephalography. Source localization of cortical activation was done with synthetic aperture magnetometry. To test for significant differences in cortical swallowing processing between groups, a non-parametric permutation test was afterwards performed on individual source localization maps.<h4>Results</h4>Swallowing task performance was comparable between groups. In relation to control subjects, in whom activation was symmetrically distributed in rostro-medial parts of the sensorimotor cortices of both hemispheres, patients showed prominent activation of the right insula, dorsolateral prefrontal cortex and lateral premotor, motor as well as inferolateral parietal cortex. Furthermore, activation was markedly reduced in the left medial primary sensory cortex as well as right medial sensorimotor cortex and adjacent supplementary motor area (p<0.01).<h4>Conclusions</h4>Functional dysphagia--a condition with assumed normal brain function--seems to be associated with distinctive changes of the swallow-related cortical activation pattern. Alterations may reflect exaggerated activation of a widely distributed vigilance, self-monitoring and salience rating network that interferes with down-stream deglutition sensorimotor control. |
| format | Article |
| id | doaj-art-550166a893e249bb87b802aea3ae98ee |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-550166a893e249bb87b802aea3ae98ee2025-08-20T03:01:11ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0192e8966510.1371/journal.pone.0089665Altered cortical swallowing processing in patients with functional dysphagia: a preliminary study.Sonja SuntrupInga TeismannAndreas WollbrinkTobias WarneckeMartin WinkelsChristo PantevRainer Dziewas<h4>Objective</h4>Current neuroimaging research on functional disturbances provides growing evidence for objective neuronal correlates of allegedly psychogenic symptoms, thereby shifting the disease concept from a psychological towards a neurobiological model. Functional dysphagia is such a rare condition, whose pathogenetic mechanism is largely unknown. In the absence of any organic reason for a patient's persistent swallowing complaints, sensorimotor processing abnormalities involving central neural pathways constitute a potential etiology.<h4>Methods</h4>In this pilot study we measured cortical swallow-related activation in 5 patients diagnosed with functional dysphagia and a matched group of healthy subjects applying magnetoencephalography. Source localization of cortical activation was done with synthetic aperture magnetometry. To test for significant differences in cortical swallowing processing between groups, a non-parametric permutation test was afterwards performed on individual source localization maps.<h4>Results</h4>Swallowing task performance was comparable between groups. In relation to control subjects, in whom activation was symmetrically distributed in rostro-medial parts of the sensorimotor cortices of both hemispheres, patients showed prominent activation of the right insula, dorsolateral prefrontal cortex and lateral premotor, motor as well as inferolateral parietal cortex. Furthermore, activation was markedly reduced in the left medial primary sensory cortex as well as right medial sensorimotor cortex and adjacent supplementary motor area (p<0.01).<h4>Conclusions</h4>Functional dysphagia--a condition with assumed normal brain function--seems to be associated with distinctive changes of the swallow-related cortical activation pattern. Alterations may reflect exaggerated activation of a widely distributed vigilance, self-monitoring and salience rating network that interferes with down-stream deglutition sensorimotor control.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089665&type=printable |
| spellingShingle | Sonja Suntrup Inga Teismann Andreas Wollbrink Tobias Warnecke Martin Winkels Christo Pantev Rainer Dziewas Altered cortical swallowing processing in patients with functional dysphagia: a preliminary study. PLoS ONE |
| title | Altered cortical swallowing processing in patients with functional dysphagia: a preliminary study. |
| title_full | Altered cortical swallowing processing in patients with functional dysphagia: a preliminary study. |
| title_fullStr | Altered cortical swallowing processing in patients with functional dysphagia: a preliminary study. |
| title_full_unstemmed | Altered cortical swallowing processing in patients with functional dysphagia: a preliminary study. |
| title_short | Altered cortical swallowing processing in patients with functional dysphagia: a preliminary study. |
| title_sort | altered cortical swallowing processing in patients with functional dysphagia a preliminary study |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089665&type=printable |
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