Developments in Platinum-Group Metals as Dual Antibacterial and Anticancer Agents
Platinum-group (PG) complexes have been used as antibacterial and anticancer agents since the discovery of cisplatin. The science world still requires improvement on these complexes because of multidrug and antineoplastic resistances. This review observes discoverers and history of these platinum-gr...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2019/5459461 |
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| author | Ayodele T. Odularu Peter A. Ajibade Johannes Z. Mbese Opeoluwa O. Oyedeji |
| author_facet | Ayodele T. Odularu Peter A. Ajibade Johannes Z. Mbese Opeoluwa O. Oyedeji |
| author_sort | Ayodele T. Odularu |
| collection | DOAJ |
| description | Platinum-group (PG) complexes have been used as antibacterial and anticancer agents since the discovery of cisplatin. The science world still requires improvement on these complexes because of multidrug and antineoplastic resistances. This review observes discoverers and history of these platinum-group metals (PGMs), as well as their beneficial applications. The focus of this study was biological applications of PGMs in relation to human health. Sandwich and half-sandwich PGM coordination compounds and their metal nanoparticles give improved results for biological activities by enhancing efficient delivery of both antibacterial and anticancer drugs, as well as luminescent bioimaging (biomarkers) for biological identifications. |
| format | Article |
| id | doaj-art-54ff8b343c5f415784347f4009c7404e |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-54ff8b343c5f415784347f4009c7404e2025-02-03T06:01:46ZengWileyJournal of Chemistry2090-90632090-90712019-01-01201910.1155/2019/54594615459461Developments in Platinum-Group Metals as Dual Antibacterial and Anticancer AgentsAyodele T. Odularu0Peter A. Ajibade1Johannes Z. Mbese2Opeoluwa O. Oyedeji3Department of Chemistry, University of Fort Hare, Private Bag X1314, Alice 5700, South AfricaSchool of Chemistry and Physics, University of KwaZulu-Natal, Pietermaritzburg Campus, Scottsville 3209, South AfricaDepartment of Chemistry, University of Fort Hare, Private Bag X1314, Alice 5700, South AfricaDepartment of Chemistry, University of Fort Hare, Private Bag X1314, Alice 5700, South AfricaPlatinum-group (PG) complexes have been used as antibacterial and anticancer agents since the discovery of cisplatin. The science world still requires improvement on these complexes because of multidrug and antineoplastic resistances. This review observes discoverers and history of these platinum-group metals (PGMs), as well as their beneficial applications. The focus of this study was biological applications of PGMs in relation to human health. Sandwich and half-sandwich PGM coordination compounds and their metal nanoparticles give improved results for biological activities by enhancing efficient delivery of both antibacterial and anticancer drugs, as well as luminescent bioimaging (biomarkers) for biological identifications.http://dx.doi.org/10.1155/2019/5459461 |
| spellingShingle | Ayodele T. Odularu Peter A. Ajibade Johannes Z. Mbese Opeoluwa O. Oyedeji Developments in Platinum-Group Metals as Dual Antibacterial and Anticancer Agents Journal of Chemistry |
| title | Developments in Platinum-Group Metals as Dual Antibacterial and Anticancer Agents |
| title_full | Developments in Platinum-Group Metals as Dual Antibacterial and Anticancer Agents |
| title_fullStr | Developments in Platinum-Group Metals as Dual Antibacterial and Anticancer Agents |
| title_full_unstemmed | Developments in Platinum-Group Metals as Dual Antibacterial and Anticancer Agents |
| title_short | Developments in Platinum-Group Metals as Dual Antibacterial and Anticancer Agents |
| title_sort | developments in platinum group metals as dual antibacterial and anticancer agents |
| url | http://dx.doi.org/10.1155/2019/5459461 |
| work_keys_str_mv | AT ayodeletodularu developmentsinplatinumgroupmetalsasdualantibacterialandanticanceragents AT peteraajibade developmentsinplatinumgroupmetalsasdualantibacterialandanticanceragents AT johanneszmbese developmentsinplatinumgroupmetalsasdualantibacterialandanticanceragents AT opeoluwaooyedeji developmentsinplatinumgroupmetalsasdualantibacterialandanticanceragents |