Fasting-mimicking diet enhances EGFR-TKI efficacy in oral cancer through dual mechanisms: direct cancer cell sensitization and tumor-associated macrophage crosstalk

Fasting-mimicking diet enhances EGFR-TKI efficacy in oral cancer through dual mechanisms: direct cancer cell sensitization and tumor-associated macrophage crosstalk

BackgroundEmerging evidence suggests the fasting-mimicking diet (FMD) offers a promising alternative to traditional calorie restriction and intermittent fasting, mitigating associated adverse effects including cachexia. Clinical trials have demonstrated the safety and efficacy of FMD, highlighting i...

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Bibliographic Details
Main Authors: Lei Wang, Yu-jie Wang, Rong Wang, Fu-lian Gong, Ji-Yuan Chen, Ya-ting Yu, Ze-rong Qiu, Yong-fang Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
fasting mimicking diets
EGFR-TKI
tumor-associated macrophages
oral cancer
CCL2
stat3
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1641024/full
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