Biomarkers of histone deacetylase inhibitor activity in a phase 1 combined-modality study with radiotherapy.

Biomarkers of histone deacetylase inhibitor activity in a phase 1 combined-modality study with radiotherapy.

<h4>Background</h4>Following the demonstration that histone deacetylase inhibitors enhanced experimental radiation-induced clonogenic suppression, the Pelvic Radiation and Vorinostat (PRAVO) phase 1 study, combining fractionated radiotherapy with daily vorinostat for pelvic carcinoma, wa...

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Main Authors: Anne Hansen Ree, Marie Grøn Saelen, Erta Kalanxhi, Ingrid H G Østensen, Kristina Schee, Kathrine Røe, Torveig Weum Abrahamsen, Svein Dueland, Kjersti Flatmark
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089750&type=printable
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