The efficacy and safety of acetylcysteine combined with budesonide nebulization in treating mycoplasma pneumonia in children: a meta-analysis
BackgroundThe aim of this meta-analysis was to systematically evaluate the clinical efficacy and safety of acetylcysteine combined with budesonide nebulization in treating Mycoplasma pneumonia in children.MethodsWe systematically searched eight electronic databases for randomized controlled trials (...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-06-01
|
| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1574257/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850117505150877696 |
|---|---|
| author | Yinan He Rongmei Huang |
| author_facet | Yinan He Rongmei Huang |
| author_sort | Yinan He |
| collection | DOAJ |
| description | BackgroundThe aim of this meta-analysis was to systematically evaluate the clinical efficacy and safety of acetylcysteine combined with budesonide nebulization in treating Mycoplasma pneumonia in children.MethodsWe systematically searched eight electronic databases for randomized controlled trials (RCTs) evaluating the use of acetylcysteine combined with budesonide nebulization in treating Mycoplasma pneumonia in children, from database inception through December 2024, and performed data analysis using a random-effects model.ResultsThe 29 RCTs involving 4,300 children were conducted. The experimental group received acetylcysteine plus budesonide treatment, while the comparison group received budesonide alone. Results showed the experimental group had a significantly higher overall clinical efficacy rate (RR = 1.16, 95% CI = 1.13–1.20, I2 = 16%). The experimental group also had a significantly lower incidence of diarrhea (RR = 0.17, 95% CI = 0.05–0.54, I2 = 0%), with no significant difference in other adverse events. The experimental group had significantly shorter times to resolution of cough (SMD = −2.11, 95% CI = −2.65 to −1.57, I2 = 97%), moist rale (SMD = −1.91, 95% CI = −2.50 to −1.33, I2 = 97%), and fever (SMD = −1.70, 95% CI = −2.26 to −1.14, I2 = 95%). Post-treatment, the experimental group had significantly lower C-reactive protein levels (SMD = −1.44, 95% CI = −1.92 to −0.97, I2 = 91%).ConclusionCompared with budesonide monotherapy, acetylcysteine combined with budesonide significantly improved the clinical efficacy in children with Mycoplasma pneumonia while not increasing the risk of adverse events, and represents a safe and effective treatment option. |
| format | Article |
| id | doaj-art-54fa206aaae447958237cf60be02ed32 |
| institution | OA Journals |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-54fa206aaae447958237cf60be02ed322025-08-20T02:36:05ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-06-011310.3389/fped.2025.15742571574257The efficacy and safety of acetylcysteine combined with budesonide nebulization in treating mycoplasma pneumonia in children: a meta-analysisYinan He0Rongmei Huang1Pediatric Intensive Care Unit, Ya'an People’s Hospital, Ya'an, ChinaDepartment of Obstetrics and Gynecology, Ya'an People’s Hospital, Ya'an, ChinaBackgroundThe aim of this meta-analysis was to systematically evaluate the clinical efficacy and safety of acetylcysteine combined with budesonide nebulization in treating Mycoplasma pneumonia in children.MethodsWe systematically searched eight electronic databases for randomized controlled trials (RCTs) evaluating the use of acetylcysteine combined with budesonide nebulization in treating Mycoplasma pneumonia in children, from database inception through December 2024, and performed data analysis using a random-effects model.ResultsThe 29 RCTs involving 4,300 children were conducted. The experimental group received acetylcysteine plus budesonide treatment, while the comparison group received budesonide alone. Results showed the experimental group had a significantly higher overall clinical efficacy rate (RR = 1.16, 95% CI = 1.13–1.20, I2 = 16%). The experimental group also had a significantly lower incidence of diarrhea (RR = 0.17, 95% CI = 0.05–0.54, I2 = 0%), with no significant difference in other adverse events. The experimental group had significantly shorter times to resolution of cough (SMD = −2.11, 95% CI = −2.65 to −1.57, I2 = 97%), moist rale (SMD = −1.91, 95% CI = −2.50 to −1.33, I2 = 97%), and fever (SMD = −1.70, 95% CI = −2.26 to −1.14, I2 = 95%). Post-treatment, the experimental group had significantly lower C-reactive protein levels (SMD = −1.44, 95% CI = −1.92 to −0.97, I2 = 91%).ConclusionCompared with budesonide monotherapy, acetylcysteine combined with budesonide significantly improved the clinical efficacy in children with Mycoplasma pneumonia while not increasing the risk of adverse events, and represents a safe and effective treatment option.https://www.frontiersin.org/articles/10.3389/fped.2025.1574257/fullmycoplasma pneumoniachildrenacetylcysteinebudesonidecurative effectmeta-analysis |
| spellingShingle | Yinan He Rongmei Huang The efficacy and safety of acetylcysteine combined with budesonide nebulization in treating mycoplasma pneumonia in children: a meta-analysis Frontiers in Pediatrics mycoplasma pneumonia children acetylcysteine budesonide curative effect meta-analysis |
| title | The efficacy and safety of acetylcysteine combined with budesonide nebulization in treating mycoplasma pneumonia in children: a meta-analysis |
| title_full | The efficacy and safety of acetylcysteine combined with budesonide nebulization in treating mycoplasma pneumonia in children: a meta-analysis |
| title_fullStr | The efficacy and safety of acetylcysteine combined with budesonide nebulization in treating mycoplasma pneumonia in children: a meta-analysis |
| title_full_unstemmed | The efficacy and safety of acetylcysteine combined with budesonide nebulization in treating mycoplasma pneumonia in children: a meta-analysis |
| title_short | The efficacy and safety of acetylcysteine combined with budesonide nebulization in treating mycoplasma pneumonia in children: a meta-analysis |
| title_sort | efficacy and safety of acetylcysteine combined with budesonide nebulization in treating mycoplasma pneumonia in children a meta analysis |
| topic | mycoplasma pneumonia children acetylcysteine budesonide curative effect meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1574257/full |
| work_keys_str_mv | AT yinanhe theefficacyandsafetyofacetylcysteinecombinedwithbudesonidenebulizationintreatingmycoplasmapneumoniainchildrenametaanalysis AT rongmeihuang theefficacyandsafetyofacetylcysteinecombinedwithbudesonidenebulizationintreatingmycoplasmapneumoniainchildrenametaanalysis AT yinanhe efficacyandsafetyofacetylcysteinecombinedwithbudesonidenebulizationintreatingmycoplasmapneumoniainchildrenametaanalysis AT rongmeihuang efficacyandsafetyofacetylcysteinecombinedwithbudesonidenebulizationintreatingmycoplasmapneumoniainchildrenametaanalysis |