CXCR4 is a response gene for parathyroid hormone which affects osteoblast and osteoclast function in vitro

CXCR4 is a response gene for parathyroid hormone which affects osteoblast and osteoclast function in vitro

Aims: To investigate the role of CXCR4 in response to teriparatide (TPTD) treatment in osteoblasts and osteoclasts. Methods: Primary murine and human osteoblasts and osteoclasts, MC3T3 cell lines, and hMSC-TERT4 cell lines were treated with TPTD and/or AMD3100, a pharmacological inhibitor of CXCR4...

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Bibliographic Details
Main Authors: Beatriz Larraz-Prieto, Louise Hjorth Lind, Jacob Bastholm Olesen, Asim Azfer, Morten Svarer Hansen, Morten Frost, Abbas Jafari, Stuart H. Ralston, Kent Søe, Nerea Alonso
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2025-05-01
Series:Bone & Joint Research
Subjects:
cxcr4
teriparatide response
osteoblasts
osteoclasts
osteoblastic cell
parathyroid hormone
teriparatide
rna
alkaline phosphatase
bone matrix
gene expression
mesenchymal stem cells
macrophages
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.145.BJR-2024-0167.R1
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