Features of Invasive Aspergillosis Caused by Aspergillus flavus, France, 2012–2018
Invasive aspergillosis (IA) caused by Aspergillus flavus remains poorly described. We retrospectively analyzed 54 cases of IA caused by A. flavus reported in France during 2012–2018. Among cases, underlying IA risk factors were malignancy, solid organ transplantation, and diabetes. Most (87%, 47/54...
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Centers for Disease Control and Prevention
2025-05-01
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| Series: | Emerging Infectious Diseases |
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| Online Access: | https://wwwnc.cdc.gov/eid/article/31/5/24-1392_article |
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| author | Lise Bertin-Biasutto Olivier Paccoud Dea Garcia-Hermoso Blandine Denis Karine Boukris-Sitbon Olivier Lortholary Stéphane Bretagne Maud Gits-Muselli Raoul Herbrecht Valérie Letscher-Bru François Danion Sophie Cassaing Florent Morio Céline Nourrisson Marc Pihet Milène Sasso Guillaume Desoubeaux Marie-Fleur Durieux Julie Bonhomme Elisabeth Chachaty Taieb Chouaki Nicole Desbois-Nogard Alexandre Alanio Jean-Pierre Gangneux Fanny Lanternier |
| author_facet | Lise Bertin-Biasutto Olivier Paccoud Dea Garcia-Hermoso Blandine Denis Karine Boukris-Sitbon Olivier Lortholary Stéphane Bretagne Maud Gits-Muselli Raoul Herbrecht Valérie Letscher-Bru François Danion Sophie Cassaing Florent Morio Céline Nourrisson Marc Pihet Milène Sasso Guillaume Desoubeaux Marie-Fleur Durieux Julie Bonhomme Elisabeth Chachaty Taieb Chouaki Nicole Desbois-Nogard Alexandre Alanio Jean-Pierre Gangneux Fanny Lanternier |
| author_sort | Lise Bertin-Biasutto |
| collection | DOAJ |
| description |
Invasive aspergillosis (IA) caused by Aspergillus flavus remains poorly described. We retrospectively analyzed 54 cases of IA caused by A. flavus reported in France during 2012–2018. Among cases, underlying IA risk factors were malignancy, solid organ transplantation, and diabetes. Most (87%, 47/54) infections were localized, of which 33 were pleuropulmonary and 13 were ear-nose-throat (ENT) infection sites. Malignancy (70% [23/33]) and solid organ transplantation (21% [7/33]) were the main risk factors in localized pulmonary infections, and diabetes mellitus was associated with localized ENT involvement (61.5%, [8/13]). Fungal co-infections were frequent in pulmonary (36%, 12/33) but not ENT IA (0 cases). Antifungal monotherapy was prescribed in 45/50 (90%) cases, mainly voriconazole (67%, 30/45). All-cause 30-day case-fatality rates were 39.2% and 90-day rates were 47.1%, and rates varied according to risk factor, IA site, and fungal co-infections. Clinicians should remain vigilant for A. flavus and consider it in the differential diagnosis for IA.
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| format | Article |
| id | doaj-art-54ef1538886747c38db073d63d69110e |
| institution | DOAJ |
| issn | 1080-6040 1080-6059 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj-art-54ef1538886747c38db073d63d69110e2025-08-20T03:19:11ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592025-05-0131589690510.3201/eid3105.241392Features of Invasive Aspergillosis Caused by Aspergillus flavus, France, 2012–2018Lise Bertin-BiasuttoOlivier PaccoudDea Garcia-HermosoBlandine DenisKarine Boukris-SitbonOlivier LortholaryStéphane BretagneMaud Gits-MuselliRaoul HerbrechtValérie Letscher-BruFrançois DanionSophie CassaingFlorent MorioCéline NourrissonMarc PihetMilène SassoGuillaume DesoubeauxMarie-Fleur DurieuxJulie BonhommeElisabeth ChachatyTaieb ChouakiNicole Desbois-NogardAlexandre AlanioJean-Pierre GangneuxFanny Lanternier Invasive aspergillosis (IA) caused by Aspergillus flavus remains poorly described. We retrospectively analyzed 54 cases of IA caused by A. flavus reported in France during 2012–2018. Among cases, underlying IA risk factors were malignancy, solid organ transplantation, and diabetes. Most (87%, 47/54) infections were localized, of which 33 were pleuropulmonary and 13 were ear-nose-throat (ENT) infection sites. Malignancy (70% [23/33]) and solid organ transplantation (21% [7/33]) were the main risk factors in localized pulmonary infections, and diabetes mellitus was associated with localized ENT involvement (61.5%, [8/13]). Fungal co-infections were frequent in pulmonary (36%, 12/33) but not ENT IA (0 cases). Antifungal monotherapy was prescribed in 45/50 (90%) cases, mainly voriconazole (67%, 30/45). All-cause 30-day case-fatality rates were 39.2% and 90-day rates were 47.1%, and rates varied according to risk factor, IA site, and fungal co-infections. Clinicians should remain vigilant for A. flavus and consider it in the differential diagnosis for IA. https://wwwnc.cdc.gov/eid/article/31/5/24-1392_articleAspergillus flavusfungiantimicrobial resistancerespiratory infectionsaspergillosisinvasive fungal infections |
| spellingShingle | Lise Bertin-Biasutto Olivier Paccoud Dea Garcia-Hermoso Blandine Denis Karine Boukris-Sitbon Olivier Lortholary Stéphane Bretagne Maud Gits-Muselli Raoul Herbrecht Valérie Letscher-Bru François Danion Sophie Cassaing Florent Morio Céline Nourrisson Marc Pihet Milène Sasso Guillaume Desoubeaux Marie-Fleur Durieux Julie Bonhomme Elisabeth Chachaty Taieb Chouaki Nicole Desbois-Nogard Alexandre Alanio Jean-Pierre Gangneux Fanny Lanternier Features of Invasive Aspergillosis Caused by Aspergillus flavus, France, 2012–2018 Emerging Infectious Diseases Aspergillus flavus fungi antimicrobial resistance respiratory infections aspergillosis invasive fungal infections |
| title | Features of Invasive Aspergillosis Caused by Aspergillus flavus, France, 2012–2018 |
| title_full | Features of Invasive Aspergillosis Caused by Aspergillus flavus, France, 2012–2018 |
| title_fullStr | Features of Invasive Aspergillosis Caused by Aspergillus flavus, France, 2012–2018 |
| title_full_unstemmed | Features of Invasive Aspergillosis Caused by Aspergillus flavus, France, 2012–2018 |
| title_short | Features of Invasive Aspergillosis Caused by Aspergillus flavus, France, 2012–2018 |
| title_sort | features of invasive aspergillosis caused by aspergillus flavus france 2012 2018 |
| topic | Aspergillus flavus fungi antimicrobial resistance respiratory infections aspergillosis invasive fungal infections |
| url | https://wwwnc.cdc.gov/eid/article/31/5/24-1392_article |
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