Cytokine dynamics in vitiligo: the roles of interleukin-10 and interleukin-17
Aim: Vitiligo is an autoimmune skin disorder characterized by melanocyte destruction and progressive depigmentation. Cytokine imbalance plays a key role in its pathogenesis. This study aims to evaluate and compare serum levels of the anti-inflammatory cytokine interleukin-10 (IL-10) and the pro-infl...
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2025-08-01
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| Series: | Exploration of Immunology |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A1003210/1003210.pdf |
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| author | Hanan Mohammed Saied |
| author_facet | Hanan Mohammed Saied |
| author_sort | Hanan Mohammed Saied |
| collection | DOAJ |
| description | Aim: Vitiligo is an autoimmune skin disorder characterized by melanocyte destruction and progressive depigmentation. Cytokine imbalance plays a key role in its pathogenesis. This study aims to evaluate and compare serum levels of the anti-inflammatory cytokine interleukin-10 (IL-10) and the pro-inflammatory cytokine IL-17 in vitiligo patients and healthy individuals, to explore their potential as biomarkers of disease activity. Methods: A total of 60 vitiligo patients and 40 age- and sex-matched healthy controls were recruited. Serum concentrations of IL-10 and IL-17 were measured using enzyme-linked immunosorbent assay (ELISA). Disease severity and duration were also assessed in relation to cytokine levels. Results: Vitiligo patients showed significantly lower IL-10 levels (9.37 ± 0.17 pg/mL) compared to controls (11.38 ± 0.22 pg/mL, P < 0.01), and significantly higher IL-17 levels (326.48 ± 5.49 pg/mL) compared to controls (270.47 ± 8.48 pg/mL, P < 0.01). Conclusions: These findings suggest an inflammatory cytokine imbalance in vitiligo, characterized by decreased IL-10 and elevated IL-17 levels. The significant correlation of IL-17 with disease progression supports its role as a potential biomarker of disease activity. Targeting cytokine pathways may offer new directions for immunomodulatory treatment strategies in vitiligo. |
| format | Article |
| id | doaj-art-54edf6960f50448c92176c86ffccafdc |
| institution | Kabale University |
| issn | 2768-6655 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Immunology |
| spelling | doaj-art-54edf6960f50448c92176c86ffccafdc2025-08-22T08:08:16ZengOpen Exploration Publishing Inc.Exploration of Immunology2768-66552025-08-015100321010.37349/ei.2025.1003210Cytokine dynamics in vitiligo: the roles of interleukin-10 and interleukin-17Hanan Mohammed Saied0https://orcid.org/0009-0008-2955-1494Biotechnology Department, College of Applied Science, University of Fallujah, Fallujah 31002, IraqAim: Vitiligo is an autoimmune skin disorder characterized by melanocyte destruction and progressive depigmentation. Cytokine imbalance plays a key role in its pathogenesis. This study aims to evaluate and compare serum levels of the anti-inflammatory cytokine interleukin-10 (IL-10) and the pro-inflammatory cytokine IL-17 in vitiligo patients and healthy individuals, to explore their potential as biomarkers of disease activity. Methods: A total of 60 vitiligo patients and 40 age- and sex-matched healthy controls were recruited. Serum concentrations of IL-10 and IL-17 were measured using enzyme-linked immunosorbent assay (ELISA). Disease severity and duration were also assessed in relation to cytokine levels. Results: Vitiligo patients showed significantly lower IL-10 levels (9.37 ± 0.17 pg/mL) compared to controls (11.38 ± 0.22 pg/mL, P < 0.01), and significantly higher IL-17 levels (326.48 ± 5.49 pg/mL) compared to controls (270.47 ± 8.48 pg/mL, P < 0.01). Conclusions: These findings suggest an inflammatory cytokine imbalance in vitiligo, characterized by decreased IL-10 and elevated IL-17 levels. The significant correlation of IL-17 with disease progression supports its role as a potential biomarker of disease activity. Targeting cytokine pathways may offer new directions for immunomodulatory treatment strategies in vitiligo.https://www.explorationpub.com/uploads/Article/A1003210/1003210.pdfvitiligoinflammatorycytokineil-10il-17 |
| spellingShingle | Hanan Mohammed Saied Cytokine dynamics in vitiligo: the roles of interleukin-10 and interleukin-17 Exploration of Immunology vitiligo inflammatory cytokine il-10 il-17 |
| title | Cytokine dynamics in vitiligo: the roles of interleukin-10 and interleukin-17 |
| title_full | Cytokine dynamics in vitiligo: the roles of interleukin-10 and interleukin-17 |
| title_fullStr | Cytokine dynamics in vitiligo: the roles of interleukin-10 and interleukin-17 |
| title_full_unstemmed | Cytokine dynamics in vitiligo: the roles of interleukin-10 and interleukin-17 |
| title_short | Cytokine dynamics in vitiligo: the roles of interleukin-10 and interleukin-17 |
| title_sort | cytokine dynamics in vitiligo the roles of interleukin 10 and interleukin 17 |
| topic | vitiligo inflammatory cytokine il-10 il-17 |
| url | https://www.explorationpub.com/uploads/Article/A1003210/1003210.pdf |
| work_keys_str_mv | AT hananmohammedsaied cytokinedynamicsinvitiligotherolesofinterleukin10andinterleukin17 |