Insights from age-stratified endoscopic detection metrics support initiating colorectal cancer screening at age 45
Abstract Background and aim All major U.S. guidelines now validate average-risk colorectal cancer (CRC) screening at 45–49 years of age. We aimed to highlight the importance of promoting colonoscopy among younger populations as part of a comprehensive strategy to reduce the burden of CRC. Methods Ou...
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BMC
2025-08-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-025-04213-2 |
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| author | Majd Khader Jorge-Shmuel Delgado Rimon Artoul Asher Shafrir Abu-Freha Naim |
| author_facet | Majd Khader Jorge-Shmuel Delgado Rimon Artoul Asher Shafrir Abu-Freha Naim |
| author_sort | Majd Khader |
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| description | Abstract Background and aim All major U.S. guidelines now validate average-risk colorectal cancer (CRC) screening at 45–49 years of age. We aimed to highlight the importance of promoting colonoscopy among younger populations as part of a comprehensive strategy to reduce the burden of CRC. Methods Our study analyzed data from 235,782 colonoscopy reports of individuals, which were categorized into six age groups: 45–49 years, 50–54 years, 55–59 years, 60–64 years, 65–69 years, and 70–74 years. Parameters such as age, gender, histopathology of polyps, quantity of polyps, and polyp detection rate (PDR) were assessed. Results Our study shows a progressive increase in colonoscopy uptake among individuals aged 45–54. PDR increased significantly with age, from 25.7% in the 45–49 group to 40.2% in the 70–74 group (p < 0.05). Notably, the PDR difference between the 45–49 and 50–54 groups was not statistically significant (25.7% vs. 26.8%, p = ns), indicating comparable polyp burden. Carcinoma detection rates followed a similar pattern, with no significant difference between the 45–49 (0.29%) and 50–54 (0.29%) groups, while a substantial rise occurred from age 55 onwards (p < 0.05). Conclusions Individuals screened in the 45–49 age group exhibited comparable PDR and carcinoma detection rates to those in the 50–54 age range. |
| format | Article |
| id | doaj-art-54e6852734ca49a8b939b43ccd2f0c52 |
| institution | Kabale University |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj-art-54e6852734ca49a8b939b43ccd2f0c522025-08-24T11:33:04ZengBMCBMC Gastroenterology1471-230X2025-08-0125111010.1186/s12876-025-04213-2Insights from age-stratified endoscopic detection metrics support initiating colorectal cancer screening at age 45Majd Khader0Jorge-Shmuel Delgado1Rimon Artoul2Asher Shafrir3Abu-Freha Naim4The Gastroenterology Institute, Assuta Medical CenterThe Gastroenterology Institute, Assuta Medical CenterGeriatrics Department, Barzilai Medical CenterThe Gastroenterology Institute, Hadassah-Hebrew University HospitalThe Gastroenterology Institute, Assuta Medical CenterAbstract Background and aim All major U.S. guidelines now validate average-risk colorectal cancer (CRC) screening at 45–49 years of age. We aimed to highlight the importance of promoting colonoscopy among younger populations as part of a comprehensive strategy to reduce the burden of CRC. Methods Our study analyzed data from 235,782 colonoscopy reports of individuals, which were categorized into six age groups: 45–49 years, 50–54 years, 55–59 years, 60–64 years, 65–69 years, and 70–74 years. Parameters such as age, gender, histopathology of polyps, quantity of polyps, and polyp detection rate (PDR) were assessed. Results Our study shows a progressive increase in colonoscopy uptake among individuals aged 45–54. PDR increased significantly with age, from 25.7% in the 45–49 group to 40.2% in the 70–74 group (p < 0.05). Notably, the PDR difference between the 45–49 and 50–54 groups was not statistically significant (25.7% vs. 26.8%, p = ns), indicating comparable polyp burden. Carcinoma detection rates followed a similar pattern, with no significant difference between the 45–49 (0.29%) and 50–54 (0.29%) groups, while a substantial rise occurred from age 55 onwards (p < 0.05). Conclusions Individuals screened in the 45–49 age group exhibited comparable PDR and carcinoma detection rates to those in the 50–54 age range.https://doi.org/10.1186/s12876-025-04213-2Colorectal cancerColorectal cancer screeningPolyp detection rate (PDR)Colonoscopy |
| spellingShingle | Majd Khader Jorge-Shmuel Delgado Rimon Artoul Asher Shafrir Abu-Freha Naim Insights from age-stratified endoscopic detection metrics support initiating colorectal cancer screening at age 45 BMC Gastroenterology Colorectal cancer Colorectal cancer screening Polyp detection rate (PDR) Colonoscopy |
| title | Insights from age-stratified endoscopic detection metrics support initiating colorectal cancer screening at age 45 |
| title_full | Insights from age-stratified endoscopic detection metrics support initiating colorectal cancer screening at age 45 |
| title_fullStr | Insights from age-stratified endoscopic detection metrics support initiating colorectal cancer screening at age 45 |
| title_full_unstemmed | Insights from age-stratified endoscopic detection metrics support initiating colorectal cancer screening at age 45 |
| title_short | Insights from age-stratified endoscopic detection metrics support initiating colorectal cancer screening at age 45 |
| title_sort | insights from age stratified endoscopic detection metrics support initiating colorectal cancer screening at age 45 |
| topic | Colorectal cancer Colorectal cancer screening Polyp detection rate (PDR) Colonoscopy |
| url | https://doi.org/10.1186/s12876-025-04213-2 |
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