Pendelluft in Chronic Obstructive Lung Disease Measured with Lung Sounds
Objective. The phenomenon of pendelluft was described over five decades ago. In patients with regional variations in resistance and elastance, gas moves at the beginning of inspiration out of some alveoli into others. Gas moves in the opposite direction at the end of inspiration. The objective of th...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/139395 |
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| author | Andrey Vyshedskiy Raymond Murphy |
| author_facet | Andrey Vyshedskiy Raymond Murphy |
| author_sort | Andrey Vyshedskiy |
| collection | DOAJ |
| description | Objective. The phenomenon of pendelluft was described over five decades ago. In patients with regional variations in resistance and elastance, gas moves at the beginning of inspiration out of some alveoli into others. Gas moves in the opposite direction at the end of inspiration. The objective of this study was to apply the method of lung sounds mapping, which is known to provide regional information about gas flow, to study pendelluft in COPD patients. Methods. A 16-channel lung sound analyzer was used to collect sounds from patients with COPD (n=90) and age-matched normals (n=90). Pendelluft at the beginning of inspiration is expected to result in vesicular sounds leading the tracheal sound by a few milliseconds. Pendelluft at the end of inspiration is expected to result in vesicular sounds lagging the tracheal sound. These lead and lag times were calculated for the 14 chest wall sites. Results. The lead time was significantly longer in COPD patients: 123±107 ms versus 48±59 ms in controls (P<0.0001). The lag time was also significantly longer in COPD patients: 269±249 ms in COPD patients versus 147±124 ms in controls (P<0.0001). When normalized by the duration of the inspiration at the trachea, the lead was 14±13% for COPD versus 4±5% for controls (P<0.0001). The lag was 28±25% for COPD versus 13±12% for controls (P<0.0001). Both lead and lag correlated moderately with the GOLD stage (correlation coefficient 0.43). Conclusion. Increased lead and lag times in COPD patients are consistent with the phenomenon of pendelluft as has been observed by other methods. |
| format | Article |
| id | doaj-art-54dd31838a484841a3f46bbe87363ad3 |
| institution | Kabale University |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-54dd31838a484841a3f46bbe87363ad32025-02-03T06:01:55ZengWileyPulmonary Medicine2090-18362090-18442012-01-01201210.1155/2012/139395139395Pendelluft in Chronic Obstructive Lung Disease Measured with Lung SoundsAndrey Vyshedskiy0Raymond Murphy1Brigham and Women's, Faulkner Hospital, Boston, MA 02130, USABrigham and Women's, Faulkner Hospital, Boston, MA 02130, USAObjective. The phenomenon of pendelluft was described over five decades ago. In patients with regional variations in resistance and elastance, gas moves at the beginning of inspiration out of some alveoli into others. Gas moves in the opposite direction at the end of inspiration. The objective of this study was to apply the method of lung sounds mapping, which is known to provide regional information about gas flow, to study pendelluft in COPD patients. Methods. A 16-channel lung sound analyzer was used to collect sounds from patients with COPD (n=90) and age-matched normals (n=90). Pendelluft at the beginning of inspiration is expected to result in vesicular sounds leading the tracheal sound by a few milliseconds. Pendelluft at the end of inspiration is expected to result in vesicular sounds lagging the tracheal sound. These lead and lag times were calculated for the 14 chest wall sites. Results. The lead time was significantly longer in COPD patients: 123±107 ms versus 48±59 ms in controls (P<0.0001). The lag time was also significantly longer in COPD patients: 269±249 ms in COPD patients versus 147±124 ms in controls (P<0.0001). When normalized by the duration of the inspiration at the trachea, the lead was 14±13% for COPD versus 4±5% for controls (P<0.0001). The lag was 28±25% for COPD versus 13±12% for controls (P<0.0001). Both lead and lag correlated moderately with the GOLD stage (correlation coefficient 0.43). Conclusion. Increased lead and lag times in COPD patients are consistent with the phenomenon of pendelluft as has been observed by other methods.http://dx.doi.org/10.1155/2012/139395 |
| spellingShingle | Andrey Vyshedskiy Raymond Murphy Pendelluft in Chronic Obstructive Lung Disease Measured with Lung Sounds Pulmonary Medicine |
| title | Pendelluft in Chronic Obstructive Lung Disease Measured with Lung Sounds |
| title_full | Pendelluft in Chronic Obstructive Lung Disease Measured with Lung Sounds |
| title_fullStr | Pendelluft in Chronic Obstructive Lung Disease Measured with Lung Sounds |
| title_full_unstemmed | Pendelluft in Chronic Obstructive Lung Disease Measured with Lung Sounds |
| title_short | Pendelluft in Chronic Obstructive Lung Disease Measured with Lung Sounds |
| title_sort | pendelluft in chronic obstructive lung disease measured with lung sounds |
| url | http://dx.doi.org/10.1155/2012/139395 |
| work_keys_str_mv | AT andreyvyshedskiy pendelluftinchronicobstructivelungdiseasemeasuredwithlungsounds AT raymondmurphy pendelluftinchronicobstructivelungdiseasemeasuredwithlungsounds |