STrengthening the REporting of Genetic Association Studies (STREGA): an extension of the STROBE statement.
Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence the ability...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2009-02-01
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| Series: | PLoS Medicine |
| Online Access: | https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1000022&type=printable |
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| author | Julian Little Julian P T Higgins John P A Ioannidis David Moher France Gagnon Erik von Elm Muin J Khoury Barbara Cohen George Davey-Smith Jeremy Grimshaw Paul Scheet Marta Gwinn Robin E Williamson Guang Yong Zou Kim Hutchings Candice Y Johnson Valerie Tait Miriam Wiens Jean Golding Cornelia van Duijn John McLaughlin Andrew Paterson George Wells Isabel Fortier Matthew Freedman Maja Zecevic Richard King Claire Infante-Rivard Alex Stewart Nick Birkett STrengthening the REporting of Genetic Association Studies |
| author_facet | Julian Little Julian P T Higgins John P A Ioannidis David Moher France Gagnon Erik von Elm Muin J Khoury Barbara Cohen George Davey-Smith Jeremy Grimshaw Paul Scheet Marta Gwinn Robin E Williamson Guang Yong Zou Kim Hutchings Candice Y Johnson Valerie Tait Miriam Wiens Jean Golding Cornelia van Duijn John McLaughlin Andrew Paterson George Wells Isabel Fortier Matthew Freedman Maja Zecevic Richard King Claire Infante-Rivard Alex Stewart Nick Birkett STrengthening the REporting of Genetic Association Studies |
| author_sort | Julian Little |
| collection | DOAJ |
| description | Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence the ability to synthesize it, has been limited by inadequate reporting of results. The STrengthening the REporting of Genetic Association studies (STREGA) initiative builds on the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement and provides additions to 12 of the 22 items on the STROBE checklist. The additions concern population stratification, genotyping errors, modelling haplotype variation, Hardy-Weinberg equilibrium, replication, selection of participants, rationale for choice of genes and variants, treatment effects in studying quantitative traits, statistical methods, relatedness, reporting of descriptive and outcome data, and the volume of data issues that are important to consider in genetic association studies. The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis. |
| format | Article |
| id | doaj-art-54da7e49e4674a61b6054de01e225df5 |
| institution | OA Journals |
| issn | 1549-1277 1549-1676 |
| language | English |
| publishDate | 2009-02-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Medicine |
| spelling | doaj-art-54da7e49e4674a61b6054de01e225df52025-08-20T02:17:20ZengPublic Library of Science (PLoS)PLoS Medicine1549-12771549-16762009-02-0162e2210.1371/journal.pmed.1000022STrengthening the REporting of Genetic Association Studies (STREGA): an extension of the STROBE statement.Julian LittleJulian P T HigginsJohn P A IoannidisDavid MoherFrance GagnonErik von ElmMuin J KhouryBarbara CohenGeorge Davey-SmithJeremy GrimshawPaul ScheetMarta GwinnRobin E WilliamsonGuang Yong ZouKim HutchingsCandice Y JohnsonValerie TaitMiriam WiensJean GoldingCornelia van DuijnJohn McLaughlinAndrew PatersonGeorge WellsIsabel FortierMatthew FreedmanMaja ZecevicRichard KingClaire Infante-RivardAlex StewartNick BirkettSTrengthening the REporting of Genetic Association StudiesMaking sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence the ability to synthesize it, has been limited by inadequate reporting of results. The STrengthening the REporting of Genetic Association studies (STREGA) initiative builds on the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement and provides additions to 12 of the 22 items on the STROBE checklist. The additions concern population stratification, genotyping errors, modelling haplotype variation, Hardy-Weinberg equilibrium, replication, selection of participants, rationale for choice of genes and variants, treatment effects in studying quantitative traits, statistical methods, relatedness, reporting of descriptive and outcome data, and the volume of data issues that are important to consider in genetic association studies. The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis.https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1000022&type=printable |
| spellingShingle | Julian Little Julian P T Higgins John P A Ioannidis David Moher France Gagnon Erik von Elm Muin J Khoury Barbara Cohen George Davey-Smith Jeremy Grimshaw Paul Scheet Marta Gwinn Robin E Williamson Guang Yong Zou Kim Hutchings Candice Y Johnson Valerie Tait Miriam Wiens Jean Golding Cornelia van Duijn John McLaughlin Andrew Paterson George Wells Isabel Fortier Matthew Freedman Maja Zecevic Richard King Claire Infante-Rivard Alex Stewart Nick Birkett STrengthening the REporting of Genetic Association Studies STrengthening the REporting of Genetic Association Studies (STREGA): an extension of the STROBE statement. PLoS Medicine |
| title | STrengthening the REporting of Genetic Association Studies (STREGA): an extension of the STROBE statement. |
| title_full | STrengthening the REporting of Genetic Association Studies (STREGA): an extension of the STROBE statement. |
| title_fullStr | STrengthening the REporting of Genetic Association Studies (STREGA): an extension of the STROBE statement. |
| title_full_unstemmed | STrengthening the REporting of Genetic Association Studies (STREGA): an extension of the STROBE statement. |
| title_short | STrengthening the REporting of Genetic Association Studies (STREGA): an extension of the STROBE statement. |
| title_sort | strengthening the reporting of genetic association studies strega an extension of the strobe statement |
| url | https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1000022&type=printable |
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