Enhancing anti-EGFRvIII CAR T cell therapy against glioblastoma with a paracrine SIRPγ-derived CD47 blocker

Enhancing anti-EGFRvIII CAR T cell therapy against glioblastoma with a paracrine SIRPγ-derived CD47 blocker

Abstract A significant challenge for chimeric antigen receptor (CAR) T cell therapy against glioblastoma (GBM) is its immunosuppressive microenvironment, which is densely populated by protumoral glioma-associated microglia and macrophages (GAMs). Myeloid immune checkpoint therapy targeting the CD47-...

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Main Authors: Tomás A. Martins, Deniz Kaymak, Nazanin Tatari, Fiona Gerster, Sabrina Hogan, Marie-Françoise Ritz, Valerio Sabatino, Ronja Wieboldt, Ewelina M. Bartoszek, Marta McDaid, Alexandra Gerber, Alicia Buck, Aisha Beshirova, Anja Heider, Tala Shekarian, Hayget Mohamed, Manina M. Etter, Philip Schmassmann, Ines Abel, Jean-Louis Boulay, Yasuyuki Saito, Luigi Mariani, Raphael Guzman, Berend Snijder, Tobias Weiss, Heinz Läubli, Gregor Hutter
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54129-w
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