Somatic Miwi2 modulates mitochondrial function in airway multiciliated cells and exacerbates influenza pathogenesis

Somatic Miwi2 modulates mitochondrial function in airway multiciliated cells and exacerbates influenza pathogenesis

Summary: MIWI2, a P element-induced wimpy testes (PIWI) argonaute protein known for suppressing retrotransposons during male gonadogenesis, has an unexplored role in mammalian somatic cells. We identify MIWI2 multiciliated (M2MC) cells as a rare subset of airway multiciliated cells and investigate M...

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Bibliographic Details
Main Authors: Jhonatan Henao Vasquez, Jin Yuan, Chi Jing Leow, Erin Crossey, Fengzhi Shao, Senegal Carty, Viviana A. Dominguez, Ming Lo, Joseph P. Mizgerd, Jessica L. Fetterman, Nelson C. Lau, Alan Fine, Matthew R. Jones
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:iScience
Subjects:
Biochemistry
Cell biology
Functional aspects of cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225005528
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