The role of HSPB1 in modulating ferroptosis in pancreatic cancer via the TP53/SLC7A11/GPX4 axis

The role of HSPB1 in modulating ferroptosis in pancreatic cancer via the TP53/SLC7A11/GPX4 axis

Abstract Purpose This study investigates the role of HSPB1 in pancreatic cancer, particularly its impact on cell proliferation and migration through ferroptosis regulation and interaction with TP53 Materials and Methods HSPB1 expression was analyzed using BioGPS and GEPIA databases. BxPC-3 cell line...

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Bibliographic Details
Main Authors: Zeyu Tian, Qi Liu, Jihui Luo, Ning Ning, Jing Qu
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Discover Oncology
Subjects:
HSPB1
Ferroptosis
Pancreatic cancer
TP53
SLC7A11
GPX4
Online Access:https://doi.org/10.1007/s12672-025-02803-w
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