Interleukin 6 and 8 Levels in Plasma and Fibroblast Cultures in Psoriasis
<p>Fibroblasts have been implicated in psoriatic inflammatory processes. The aim of the study was to evaluate soluble interleukin 2 receptor (sIL-2R), interleukin 6 (IL-6), and interleukin 8 (IL-8) plasma levels in psoriatic patients and IL-6 and IL-8 levels in fibroblast culture supernatants....
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| Format: | Article |
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| Language: | English |
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Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://www.hindawi.com/GetArticle.aspx?doi=10.1155/MI/2006/81767 |
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| description | <p>Fibroblasts have been implicated in psoriatic inflammatory processes. The aim of the study was to evaluate soluble interleukin 2 receptor (sIL-2R), interleukin 6 (IL-6), and interleukin 8 (IL-8) plasma levels in psoriatic patients and IL-6 and IL-8 levels in fibroblast culture supernatants. Cytokines levels in plasma and supernatants were measured by ELISA. Plasma sIL-2R, IL-6, and IL-8 levels were higher before the treatment in comparison to healthy controls (<mml:math alttext="$P<0.001$"> <mml:mi>P</mml:mi> <mml:mo><</mml:mo> <mml:mn>0.001</mml:mn> </mml:math>) and decreased after treatment. Fibroblasts from healthy controls, psoriatic lesional skin, and noninvolved psoriatic skin, when stimulated with tumor necrosis factor alpha, released considerable amounts of IL-6 and IL-8. No significant difference between healthy controls and psoriatic fibroblasts was observed. Monitoring plasma sIL-2R levels could be employed as a reliable method of psoriasis activity. IL-8 and IL-6 plasma levels seem to reflect psoriasis activity, and treatment response, respectively. Fibroblasts are not a major source of increased IL-6 and IL-8 production in psoriasis.</p> |
| format | Article |
| id | doaj-art-54d6baccc6694e57ae053643d94d6a71 |
| institution | Kabale University |
| issn | 0962-9351 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-54d6baccc6694e57ae053643d94d6a712025-02-03T05:43:53ZengWileyMediators of Inflammation0962-93512006-01-012006Interleukin 6 and 8 Levels in Plasma and Fibroblast Cultures in Psoriasis<p>Fibroblasts have been implicated in psoriatic inflammatory processes. The aim of the study was to evaluate soluble interleukin 2 receptor (sIL-2R), interleukin 6 (IL-6), and interleukin 8 (IL-8) plasma levels in psoriatic patients and IL-6 and IL-8 levels in fibroblast culture supernatants. Cytokines levels in plasma and supernatants were measured by ELISA. Plasma sIL-2R, IL-6, and IL-8 levels were higher before the treatment in comparison to healthy controls (<mml:math alttext="$P<0.001$"> <mml:mi>P</mml:mi> <mml:mo><</mml:mo> <mml:mn>0.001</mml:mn> </mml:math>) and decreased after treatment. Fibroblasts from healthy controls, psoriatic lesional skin, and noninvolved psoriatic skin, when stimulated with tumor necrosis factor alpha, released considerable amounts of IL-6 and IL-8. No significant difference between healthy controls and psoriatic fibroblasts was observed. Monitoring plasma sIL-2R levels could be employed as a reliable method of psoriasis activity. IL-8 and IL-6 plasma levels seem to reflect psoriasis activity, and treatment response, respectively. Fibroblasts are not a major source of increased IL-6 and IL-8 production in psoriasis.</p>http://www.hindawi.com/GetArticle.aspx?doi=10.1155/MI/2006/81767 |
| spellingShingle | Interleukin 6 and 8 Levels in Plasma and Fibroblast Cultures in Psoriasis Mediators of Inflammation |
| title | Interleukin 6 and 8 Levels in Plasma and Fibroblast Cultures in Psoriasis |
| title_full | Interleukin 6 and 8 Levels in Plasma and Fibroblast Cultures in Psoriasis |
| title_fullStr | Interleukin 6 and 8 Levels in Plasma and Fibroblast Cultures in Psoriasis |
| title_full_unstemmed | Interleukin 6 and 8 Levels in Plasma and Fibroblast Cultures in Psoriasis |
| title_short | Interleukin 6 and 8 Levels in Plasma and Fibroblast Cultures in Psoriasis |
| title_sort | interleukin 6 and 8 levels in plasma and fibroblast cultures in psoriasis |
| url | http://www.hindawi.com/GetArticle.aspx?doi=10.1155/MI/2006/81767 |