Sex disparity in the association between alcohol consumption and sarcopenia: a population-based study
BackgroundPrevious studies have shown inconsistent findings regarding the association of alcohol consumption with sarcopenia. Therefore, this study comprehensively investigated the association of alcohol consumption with sarcopenia in a nationally representative sample of US adults.MethodsThis popul...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1536488/full |
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| author | Longbao Yang Longbao Yang Qiuju Ran Qiuju Ran Yee Hui Yeo Zhang Wen Zhang Wen Shuyue Tuo Shuyue Tuo Yong Li Yong Li Jia Yuan Jia Yuan Shejiao Dai Shejiao Dai Jinhai Wang Jinhai Wang Fanpu Ji Fanpu Ji Fanpu Ji Fanpu Ji Xinxing Tantai Xinxing Tantai |
| author_facet | Longbao Yang Longbao Yang Qiuju Ran Qiuju Ran Yee Hui Yeo Zhang Wen Zhang Wen Shuyue Tuo Shuyue Tuo Yong Li Yong Li Jia Yuan Jia Yuan Shejiao Dai Shejiao Dai Jinhai Wang Jinhai Wang Fanpu Ji Fanpu Ji Fanpu Ji Fanpu Ji Xinxing Tantai Xinxing Tantai |
| author_sort | Longbao Yang |
| collection | DOAJ |
| description | BackgroundPrevious studies have shown inconsistent findings regarding the association of alcohol consumption with sarcopenia. Therefore, this study comprehensively investigated the association of alcohol consumption with sarcopenia in a nationally representative sample of US adults.MethodsThis population-based study included adults aged 18 years and older from the National Health and Nutrition Examination Survey (NHANES) III. Alcohol exposure was defined as daily alcohol intake, alcohol drinking history, number of drinking days per week, and frequency of binge drinking days per month. Weighted logistic regressions were used to determine associations.ResultsFour cohorts were selected from the NHANES III: cohort 1 (n = 7,592), cohort 2 (n = 12,060), cohort 3 (n = 7,608), and cohort 4 (n = 7,649), corresponding to alcohol exposure categories of daily alcohol intake, drinking history, number of drinking days per week, and frequency of binge drinking days per month. In the full model, the risk of sarcopenia was significantly associated with mild (odds ratio [OR]: 1.65; 95% confidence interval [CI]: 1.08–2.51), moderate (OR: 2.04; 95% CI: 1.12–3.71), and heavy drinkers (OR: 2.42; 95% CI: 1.17–4.97) compared to nondrinkers. There was an association between the development of sarcopenia and current drinkers (OR: 1.69; 95% CI: 1.12–2.56) but not former drinkers (OR: 1.21; 95% CI: 0.88–1.66). Compared to nondrinkers, an increased risk of developing sarcopenia was observed in participants who consumed alcohol 2 days (OR: 2.36; 95% CI: 1.40–3.99) or > 2 days (OR: 1.84; 95% CI: 1.10–3.07) per week, and those who engaged in binge drinking for ≤1 day per month (OR: 1.68; 95% CI: 1.09–2.60) or > 1 day per month (OR: 2.10; 95% CI: 1.10–4.01). Sensitivity analyses based on different definitions of sarcopenia yielded similar results. Stratified analyses revealed that these associations were present in females but not males.ConclusionAlcohol intake was associated with an increased risk of sarcopenia in all individuals, with this association being primarily observed in females rather than males. |
| format | Article |
| id | doaj-art-54d38ba86d844436a188921621979635 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-02-01 |
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| spelling | doaj-art-54d38ba86d844436a1889216219796352025-02-07T05:10:33ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-02-011210.3389/fnut.2025.15364881536488Sex disparity in the association between alcohol consumption and sarcopenia: a population-based studyLongbao Yang0Longbao Yang1Qiuju Ran2Qiuju Ran3Yee Hui Yeo4Zhang Wen5Zhang Wen6Shuyue Tuo7Shuyue Tuo8Yong Li9Yong Li10Jia Yuan11Jia Yuan12Shejiao Dai13Shejiao Dai14Jinhai Wang15Jinhai Wang16Fanpu Ji17Fanpu Ji18Fanpu Ji19Fanpu Ji20Xinxing Tantai21Xinxing Tantai22Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaClinical Research Center for Gastrointestinal Diseases of Shaanxi Province, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaDepartment of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaClinical Research Center for Gastrointestinal Diseases of Shaanxi Province, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaKarsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesDepartment of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaClinical Research Center for Gastrointestinal Diseases of Shaanxi Province, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaDepartment of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaClinical Research Center for Gastrointestinal Diseases of Shaanxi Province, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaDepartment of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaClinical Research Center for Gastrointestinal Diseases of Shaanxi Province, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaDepartment of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaClinical Research Center for Gastrointestinal Diseases of Shaanxi Province, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaDepartment of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaClinical Research Center for Gastrointestinal Diseases of Shaanxi Province, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaDepartment of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaClinical Research Center for Gastrointestinal Diseases of Shaanxi Province, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaDepartment of Infectious Diseases, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaNational & Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaShaanxi Provincial Clinical Research Center for Hepatic & Splenic Diseases, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaKey Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Ministry of Education of China, Xi'an, ChinaDepartment of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaClinical Research Center for Gastrointestinal Diseases of Shaanxi Province, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaBackgroundPrevious studies have shown inconsistent findings regarding the association of alcohol consumption with sarcopenia. Therefore, this study comprehensively investigated the association of alcohol consumption with sarcopenia in a nationally representative sample of US adults.MethodsThis population-based study included adults aged 18 years and older from the National Health and Nutrition Examination Survey (NHANES) III. Alcohol exposure was defined as daily alcohol intake, alcohol drinking history, number of drinking days per week, and frequency of binge drinking days per month. Weighted logistic regressions were used to determine associations.ResultsFour cohorts were selected from the NHANES III: cohort 1 (n = 7,592), cohort 2 (n = 12,060), cohort 3 (n = 7,608), and cohort 4 (n = 7,649), corresponding to alcohol exposure categories of daily alcohol intake, drinking history, number of drinking days per week, and frequency of binge drinking days per month. In the full model, the risk of sarcopenia was significantly associated with mild (odds ratio [OR]: 1.65; 95% confidence interval [CI]: 1.08–2.51), moderate (OR: 2.04; 95% CI: 1.12–3.71), and heavy drinkers (OR: 2.42; 95% CI: 1.17–4.97) compared to nondrinkers. There was an association between the development of sarcopenia and current drinkers (OR: 1.69; 95% CI: 1.12–2.56) but not former drinkers (OR: 1.21; 95% CI: 0.88–1.66). Compared to nondrinkers, an increased risk of developing sarcopenia was observed in participants who consumed alcohol 2 days (OR: 2.36; 95% CI: 1.40–3.99) or > 2 days (OR: 1.84; 95% CI: 1.10–3.07) per week, and those who engaged in binge drinking for ≤1 day per month (OR: 1.68; 95% CI: 1.09–2.60) or > 1 day per month (OR: 2.10; 95% CI: 1.10–4.01). Sensitivity analyses based on different definitions of sarcopenia yielded similar results. Stratified analyses revealed that these associations were present in females but not males.ConclusionAlcohol intake was associated with an increased risk of sarcopenia in all individuals, with this association being primarily observed in females rather than males.https://www.frontiersin.org/articles/10.3389/fnut.2025.1536488/fullalcoholsarcopeniasexNHANEScross-sectional study |
| spellingShingle | Longbao Yang Longbao Yang Qiuju Ran Qiuju Ran Yee Hui Yeo Zhang Wen Zhang Wen Shuyue Tuo Shuyue Tuo Yong Li Yong Li Jia Yuan Jia Yuan Shejiao Dai Shejiao Dai Jinhai Wang Jinhai Wang Fanpu Ji Fanpu Ji Fanpu Ji Fanpu Ji Xinxing Tantai Xinxing Tantai Sex disparity in the association between alcohol consumption and sarcopenia: a population-based study Frontiers in Nutrition alcohol sarcopenia sex NHANES cross-sectional study |
| title | Sex disparity in the association between alcohol consumption and sarcopenia: a population-based study |
| title_full | Sex disparity in the association between alcohol consumption and sarcopenia: a population-based study |
| title_fullStr | Sex disparity in the association between alcohol consumption and sarcopenia: a population-based study |
| title_full_unstemmed | Sex disparity in the association between alcohol consumption and sarcopenia: a population-based study |
| title_short | Sex disparity in the association between alcohol consumption and sarcopenia: a population-based study |
| title_sort | sex disparity in the association between alcohol consumption and sarcopenia a population based study |
| topic | alcohol sarcopenia sex NHANES cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1536488/full |
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