Hemoglobin-loaded hollow mesoporous carbon-gold nanocomposites enhance microwave ablation through hypoxia relief
Abstract Microwave ablation, as a critical minimally invasive technique for tumor treatment, remains challenging in achieving an optimal balance between incomplete and excessive ablation. In addition to selectively elevating the temperature of tumor lesions through the microwave thermal effect, micr...
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BMC
2025-04-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-025-03387-x |
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| author | Yitian Zhang Bitao Li Jiawen He Ya Meng Meixiao Zhan Cuixia Lu Yong Li Feiyu Niu Liewei Wen |
| author_facet | Yitian Zhang Bitao Li Jiawen He Ya Meng Meixiao Zhan Cuixia Lu Yong Li Feiyu Niu Liewei Wen |
| author_sort | Yitian Zhang |
| collection | DOAJ |
| description | Abstract Microwave ablation, as a critical minimally invasive technique for tumor treatment, remains challenging in achieving an optimal balance between incomplete and excessive ablation. In addition to selectively elevating the temperature of tumor lesions through the microwave thermal effect, microwave-responsive nanoparticles can also improve the efficacy of single-session ablation by generating reactive oxygen species (ROS) via the microwave dynamic effect, thereby mitigating the thermal damage to normal tissues caused by high temperature. In this study, ultra-small gold nanoparticles anchored hollow mesoporous carbon nanoparticles (HMCNs) are loaded with hemoglobin (Hb) to serve as microwave ablation nano-sensitizers (HMCN/Au@Hb), which will amplify the microwave dynamic effect by alleviating the hypoxic microenvironment of tumors. Upon microwave irradiation, HMCN/Au@Hb not only improves the microwave-thermal conversion efficiency of tumor lesion but also promotes the ROS generation by increasing oxygen content in the hypoxic tumor microenvironment. More importantly, we found that the hypoxia relief will improve the antitumor response and further enhance the clearance of residual tumor after ablation. Nearly complete ablation was achieved in certain tumor-bearing mice, with no recurrence of the primary tumor observed up to 33 days post-ablation. In comparison to traditional microwave ablation, the survival time of the tumor-bearing mice was significantly extended. Therefore, this work presents an innovative ablation sensitization strategy based on the hypoxia relief and provides a nanosensitizer for microwave ablation integrating great microwave-thermal and dynamic effects along with immune modulation capabilities. |
| format | Article |
| id | doaj-art-54cd6667ce9e457ba6845f11367716c8 |
| institution | OA Journals |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
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| series | Journal of Nanobiotechnology |
| spelling | doaj-art-54cd6667ce9e457ba6845f11367716c82025-08-20T02:11:11ZengBMCJournal of Nanobiotechnology1477-31552025-04-0123111410.1186/s12951-025-03387-xHemoglobin-loaded hollow mesoporous carbon-gold nanocomposites enhance microwave ablation through hypoxia reliefYitian Zhang0Bitao Li1Jiawen He2Ya Meng3Meixiao Zhan4Cuixia Lu5Yong Li6Feiyu Niu7Liewei Wen8Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai People’s Hospital (The Affiliated Hospital of Beijing Institute of Technology), Beijing Institute of TechnologyZhuhai Clinical Medical College of Jinan University (Zhuhai People’s Hospital, The Affiliated Hospital of Beijing Institute of Technology)Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai People’s Hospital (The Affiliated Hospital of Beijing Institute of Technology), Beijing Institute of TechnologyGuangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai People’s Hospital (The Affiliated Hospital of Beijing Institute of Technology), Beijing Institute of TechnologyGuangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical UniversityMedical College, Guangxi UniversityGuangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai People’s Hospital (The Affiliated Hospital of Beijing Institute of Technology), Beijing Institute of TechnologyGuangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical UniversityGuangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai People’s Hospital (The Affiliated Hospital of Beijing Institute of Technology), Beijing Institute of TechnologyAbstract Microwave ablation, as a critical minimally invasive technique for tumor treatment, remains challenging in achieving an optimal balance between incomplete and excessive ablation. In addition to selectively elevating the temperature of tumor lesions through the microwave thermal effect, microwave-responsive nanoparticles can also improve the efficacy of single-session ablation by generating reactive oxygen species (ROS) via the microwave dynamic effect, thereby mitigating the thermal damage to normal tissues caused by high temperature. In this study, ultra-small gold nanoparticles anchored hollow mesoporous carbon nanoparticles (HMCNs) are loaded with hemoglobin (Hb) to serve as microwave ablation nano-sensitizers (HMCN/Au@Hb), which will amplify the microwave dynamic effect by alleviating the hypoxic microenvironment of tumors. Upon microwave irradiation, HMCN/Au@Hb not only improves the microwave-thermal conversion efficiency of tumor lesion but also promotes the ROS generation by increasing oxygen content in the hypoxic tumor microenvironment. More importantly, we found that the hypoxia relief will improve the antitumor response and further enhance the clearance of residual tumor after ablation. Nearly complete ablation was achieved in certain tumor-bearing mice, with no recurrence of the primary tumor observed up to 33 days post-ablation. In comparison to traditional microwave ablation, the survival time of the tumor-bearing mice was significantly extended. Therefore, this work presents an innovative ablation sensitization strategy based on the hypoxia relief and provides a nanosensitizer for microwave ablation integrating great microwave-thermal and dynamic effects along with immune modulation capabilities.https://doi.org/10.1186/s12951-025-03387-xMicrowave ablationHypoxia reliefMicrowave dynamic effectNanoparticlesAntitumor immune response |
| spellingShingle | Yitian Zhang Bitao Li Jiawen He Ya Meng Meixiao Zhan Cuixia Lu Yong Li Feiyu Niu Liewei Wen Hemoglobin-loaded hollow mesoporous carbon-gold nanocomposites enhance microwave ablation through hypoxia relief Journal of Nanobiotechnology Microwave ablation Hypoxia relief Microwave dynamic effect Nanoparticles Antitumor immune response |
| title | Hemoglobin-loaded hollow mesoporous carbon-gold nanocomposites enhance microwave ablation through hypoxia relief |
| title_full | Hemoglobin-loaded hollow mesoporous carbon-gold nanocomposites enhance microwave ablation through hypoxia relief |
| title_fullStr | Hemoglobin-loaded hollow mesoporous carbon-gold nanocomposites enhance microwave ablation through hypoxia relief |
| title_full_unstemmed | Hemoglobin-loaded hollow mesoporous carbon-gold nanocomposites enhance microwave ablation through hypoxia relief |
| title_short | Hemoglobin-loaded hollow mesoporous carbon-gold nanocomposites enhance microwave ablation through hypoxia relief |
| title_sort | hemoglobin loaded hollow mesoporous carbon gold nanocomposites enhance microwave ablation through hypoxia relief |
| topic | Microwave ablation Hypoxia relief Microwave dynamic effect Nanoparticles Antitumor immune response |
| url | https://doi.org/10.1186/s12951-025-03387-x |
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