Cerebral Hemodynamic Changes during the Trigeminocardiac Reflex: Description of a New Animal Model Protocol
The trigeminocardiac reflex (TCR) is a well-known brainstem reflex, first described in skull base and neurosurgery by the senior author in 1999, leading to reflex apnea, bradycardia, and changes of mean arterial pressure. There seem to be differences between peripheral and central stimulation of the...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2010.136 |
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| author | N. Sandu J. Cornelius A. Filis C. Nöthen J. Rasper V. I. Kulinsky B. J. Schaller |
| author_facet | N. Sandu J. Cornelius A. Filis C. Nöthen J. Rasper V. I. Kulinsky B. J. Schaller |
| author_sort | N. Sandu |
| collection | DOAJ |
| description | The trigeminocardiac reflex (TCR) is a well-known brainstem reflex, first described in skull base and neurosurgery by the senior author in 1999, leading to reflex apnea, bradycardia, and changes of mean arterial pressure. There seem to be differences between peripheral and central stimulation of the TCR, and there is a lack of clear data about the cerebral hemodynamic changes during the TCR. However, the research of this reflex principally focused on clinical cases for peripheral and central stimulation during the last years, and on rabbits for peripheral stimulation several decades ago, so there was a need for an animal model that allows us to use the current state-of-the-art imaging methods. The new animal model protocol as introduced by the authors gives, for the first time, deep insights into the cerebral hemodynamic changes during the TCR and gives substantial evidence whether the TCR represents an oxygen-conserving reflex or not. |
| format | Article |
| id | doaj-art-54cd50e3e49d48c8a7a3e6c0bcadefb9 |
| institution | OA Journals |
| issn | 1537-744X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-54cd50e3e49d48c8a7a3e6c0bcadefb92025-08-20T02:05:07ZengWileyThe Scientific World Journal1537-744X2010-01-01101416142310.1100/tsw.2010.136Cerebral Hemodynamic Changes during the Trigeminocardiac Reflex: Description of a New Animal Model ProtocolN. Sandu0J. Cornelius1A. Filis2C. Nöthen3J. Rasper4V. I. Kulinsky5B. J. Schaller6Neurosurgical Department, University of Paris, FranceNeurosurgical Department, University of Paris, FranceNeurosurgical Department, University of Erlangen, GermanyNeurosurgical Department, University of Erlangen, GermanyNeurosurgical Department, University of Münster, GermanyBiochemistry Department, Irkutsk State Medical University, Irkutsk, RussiaNeurosurgical Department, University of Paris, FranceThe trigeminocardiac reflex (TCR) is a well-known brainstem reflex, first described in skull base and neurosurgery by the senior author in 1999, leading to reflex apnea, bradycardia, and changes of mean arterial pressure. There seem to be differences between peripheral and central stimulation of the TCR, and there is a lack of clear data about the cerebral hemodynamic changes during the TCR. However, the research of this reflex principally focused on clinical cases for peripheral and central stimulation during the last years, and on rabbits for peripheral stimulation several decades ago, so there was a need for an animal model that allows us to use the current state-of-the-art imaging methods. The new animal model protocol as introduced by the authors gives, for the first time, deep insights into the cerebral hemodynamic changes during the TCR and gives substantial evidence whether the TCR represents an oxygen-conserving reflex or not.http://dx.doi.org/10.1100/tsw.2010.136 |
| spellingShingle | N. Sandu J. Cornelius A. Filis C. Nöthen J. Rasper V. I. Kulinsky B. J. Schaller Cerebral Hemodynamic Changes during the Trigeminocardiac Reflex: Description of a New Animal Model Protocol The Scientific World Journal |
| title | Cerebral Hemodynamic Changes during the Trigeminocardiac Reflex: Description of a New Animal Model Protocol |
| title_full | Cerebral Hemodynamic Changes during the Trigeminocardiac Reflex: Description of a New Animal Model Protocol |
| title_fullStr | Cerebral Hemodynamic Changes during the Trigeminocardiac Reflex: Description of a New Animal Model Protocol |
| title_full_unstemmed | Cerebral Hemodynamic Changes during the Trigeminocardiac Reflex: Description of a New Animal Model Protocol |
| title_short | Cerebral Hemodynamic Changes during the Trigeminocardiac Reflex: Description of a New Animal Model Protocol |
| title_sort | cerebral hemodynamic changes during the trigeminocardiac reflex description of a new animal model protocol |
| url | http://dx.doi.org/10.1100/tsw.2010.136 |
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