Identification and validation of M2 macrophage-related gene signature as a novel prognostic model for head and neck squamous cell carcinoma
Abstract Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous tumor. Commonly used tumor staging don’t sufficiently and accurately assess the prognosis of HNSCC patients, resulting in a lack of guidance for clinical treatment decisions. M2 macrophage infiltration has been shown to...
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Nature Portfolio
2024-10-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-76866-0 |
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| author | Shengmei He Huarong Chen Changya Li Bao Feng Ruizhe Zhang Houyu Zhao Xianlu Zhuo |
| author_facet | Shengmei He Huarong Chen Changya Li Bao Feng Ruizhe Zhang Houyu Zhao Xianlu Zhuo |
| author_sort | Shengmei He |
| collection | DOAJ |
| description | Abstract Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous tumor. Commonly used tumor staging don’t sufficiently and accurately assess the prognosis of HNSCC patients, resulting in a lack of guidance for clinical treatment decisions. M2 macrophage infiltration has been shown to be strongly associated with the tumor prognosis. In this study, we used the Cancer Genome Atlas (TCGA) data to screen for genes co-expressed with M2 macrophages in HNSCC. We used univariate Cox regression to screen out the genes associated with HNSCC prognosis, and constructed a HNSCC prognosis model by Lasso regression analysis. The results confirmed that the model had good predictive value and accuracy for the prognosis of HNSCC patients by survival analysis, ROC curve and nomogram. We divided the HNSCC samples into high-risk and low-risk groups according to the risk score, and the results showed that patients in the high-risk group were more prone to genetic mutations and had a higher tumor mutational burden. In addition, there were significant differences between risk groups in terms of immune cell infiltration and drug sensitivity. The HNSCC prognostic model established in this study may provide guidance for clinical therapeutic decision-making and provide a theoretical foundation for the development of new immunotherapy methods. |
| format | Article |
| id | doaj-art-54cbbafd8ab7410294c039ea8c3eaa09 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-54cbbafd8ab7410294c039ea8c3eaa092025-08-20T02:11:17ZengNature PortfolioScientific Reports2045-23222024-10-0114111410.1038/s41598-024-76866-0Identification and validation of M2 macrophage-related gene signature as a novel prognostic model for head and neck squamous cell carcinomaShengmei He0Huarong Chen1Changya Li2Bao Feng3Ruizhe Zhang4Houyu Zhao5Xianlu Zhuo6Department of Otorhinolaryngology Head and Neck Surgery, The Affiliated Hospital of Guizhou Medical UniversityDepartment of Otorhinolaryngology Head and Neck Surgery, The Affiliated Hospital of Guizhou Medical UniversityDepartment of Otorhinolaryngology Head and Neck Surgery, The Affiliated Hospital of Guizhou Medical UniversitySchool of clinical medicine, Guizhou Medical UniversitySchool of clinical medicine, Guizhou Medical UniversityDepartment of Otorhinolaryngology Head and Neck Surgery, The Affiliated Hospital of Guizhou Medical UniversityDepartment of Otorhinolaryngology Head and Neck Surgery, The Affiliated Hospital of Guizhou Medical UniversityAbstract Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous tumor. Commonly used tumor staging don’t sufficiently and accurately assess the prognosis of HNSCC patients, resulting in a lack of guidance for clinical treatment decisions. M2 macrophage infiltration has been shown to be strongly associated with the tumor prognosis. In this study, we used the Cancer Genome Atlas (TCGA) data to screen for genes co-expressed with M2 macrophages in HNSCC. We used univariate Cox regression to screen out the genes associated with HNSCC prognosis, and constructed a HNSCC prognosis model by Lasso regression analysis. The results confirmed that the model had good predictive value and accuracy for the prognosis of HNSCC patients by survival analysis, ROC curve and nomogram. We divided the HNSCC samples into high-risk and low-risk groups according to the risk score, and the results showed that patients in the high-risk group were more prone to genetic mutations and had a higher tumor mutational burden. In addition, there were significant differences between risk groups in terms of immune cell infiltration and drug sensitivity. The HNSCC prognostic model established in this study may provide guidance for clinical therapeutic decision-making and provide a theoretical foundation for the development of new immunotherapy methods.https://doi.org/10.1038/s41598-024-76866-0M2 macrophageHead and neck squamous cell carcinomaImmune infiltrationPrognostic model |
| spellingShingle | Shengmei He Huarong Chen Changya Li Bao Feng Ruizhe Zhang Houyu Zhao Xianlu Zhuo Identification and validation of M2 macrophage-related gene signature as a novel prognostic model for head and neck squamous cell carcinoma Scientific Reports M2 macrophage Head and neck squamous cell carcinoma Immune infiltration Prognostic model |
| title | Identification and validation of M2 macrophage-related gene signature as a novel prognostic model for head and neck squamous cell carcinoma |
| title_full | Identification and validation of M2 macrophage-related gene signature as a novel prognostic model for head and neck squamous cell carcinoma |
| title_fullStr | Identification and validation of M2 macrophage-related gene signature as a novel prognostic model for head and neck squamous cell carcinoma |
| title_full_unstemmed | Identification and validation of M2 macrophage-related gene signature as a novel prognostic model for head and neck squamous cell carcinoma |
| title_short | Identification and validation of M2 macrophage-related gene signature as a novel prognostic model for head and neck squamous cell carcinoma |
| title_sort | identification and validation of m2 macrophage related gene signature as a novel prognostic model for head and neck squamous cell carcinoma |
| topic | M2 macrophage Head and neck squamous cell carcinoma Immune infiltration Prognostic model |
| url | https://doi.org/10.1038/s41598-024-76866-0 |
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