The impact of COVID‐19 severity on adult survivors: Is there a relationship between vascular reactivity and cardiorespiratory fitness?
Abstract The impact of COVID‐19 on cardiorespiratory fitness (CRF) is negative, increasing the likelihood of exertional symptoms such as fatigue and shortness of breath, and adversely affecting vascular function, impairing cardiovascular health. This study investigated endothelial function and its r...
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| Format: | Article |
| Language: | English |
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Wiley
2025-03-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.70216 |
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| author | Guilherme Dionir Back Murilo Rezende Oliveira Guilherme Peixoto Tinoco Arêas Patricia Faria Camargo Cássia daLuz Goulart Claudio Ricardo deOliveira José Carlos Bonjorno Junior Flávia Rossi Caruso Bonjourno Ross Arena Audrey Borghi‐Silva |
| author_facet | Guilherme Dionir Back Murilo Rezende Oliveira Guilherme Peixoto Tinoco Arêas Patricia Faria Camargo Cássia daLuz Goulart Claudio Ricardo deOliveira José Carlos Bonjorno Junior Flávia Rossi Caruso Bonjourno Ross Arena Audrey Borghi‐Silva |
| author_sort | Guilherme Dionir Back |
| collection | DOAJ |
| description | Abstract The impact of COVID‐19 on cardiorespiratory fitness (CRF) is negative, increasing the likelihood of exertional symptoms such as fatigue and shortness of breath, and adversely affecting vascular function, impairing cardiovascular health. This study investigated endothelial function and its relationship with CRF in patients who have recovered COVID‐19. Patients were evaluated 1 month after infection, including clinical assessment, pulmonary function, endothelial function (measured by flow‐mediated dilation), and cardiopulmonary exercise testing. COVID‐19 survivors exhibited reduced exercise capacity, with poor values of peak V̇O2peak and FMD (%) according to disease severity. However, endothelial function was worse in COVID‐19 patients, regardless of severity, compared to the control group. Significant associations were observed between poorer FMD (%) and peak V̇O2, workload, circulatory power, and V̇O2peak/WR. Endothelial function was significantly associated with CRF in COVID‐19 patients according to disease severity. Strategies to improve CRF and reduce the negative impacts of endothelial function damage should be further investigated. |
| format | Article |
| id | doaj-art-54c8a7e9b7b64476aa6b40f129f55edc |
| institution | OA Journals |
| issn | 2051-817X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj-art-54c8a7e9b7b64476aa6b40f129f55edc2025-08-20T01:51:39ZengWileyPhysiological Reports2051-817X2025-03-01135n/an/a10.14814/phy2.70216The impact of COVID‐19 severity on adult survivors: Is there a relationship between vascular reactivity and cardiorespiratory fitness?Guilherme Dionir Back0Murilo Rezende Oliveira1Guilherme Peixoto Tinoco Arêas2Patricia Faria Camargo3Cássia daLuz Goulart4Claudio Ricardo deOliveira5José Carlos Bonjorno Junior6Flávia Rossi Caruso Bonjourno7Ross Arena8Audrey Borghi‐Silva9Cardiopulmonary Physiotherapy Laboratory, Physiotherapy Department Federal University of São Carlos, UFSCar São Carlos BrazilCardiopulmonary Physiotherapy Laboratory, Physiotherapy Department Federal University of São Carlos, UFSCar São Carlos BrazilExercise Physiology Laboratory, College of Physical Education and Physiotherapy (FEFF) Federal University of Amazonas Manaus BrazilCardiopulmonary Physiotherapy Laboratory, Physiotherapy Department Federal University of São Carlos, UFSCar São Carlos BrazilCardiopulmonary Physiotherapy Laboratory, Physiotherapy Department Federal University of São Carlos, UFSCar São Carlos BrazilCardiopulmonary Physiotherapy Laboratory, Physiotherapy Department Federal University of São Carlos, UFSCar São Carlos BrazilCardiopulmonary Physiotherapy Laboratory, Physiotherapy Department Federal University of São Carlos, UFSCar São Carlos BrazilCardiopulmonary Physiotherapy Laboratory, Physiotherapy Department Federal University of São Carlos, UFSCar São Carlos BrazilDepartment of Physical Therapy, College of Applied Health Sciences University of Illinois Chicago Chicago Illinois USACardiopulmonary Physiotherapy Laboratory, Physiotherapy Department Federal University of São Carlos, UFSCar São Carlos BrazilAbstract The impact of COVID‐19 on cardiorespiratory fitness (CRF) is negative, increasing the likelihood of exertional symptoms such as fatigue and shortness of breath, and adversely affecting vascular function, impairing cardiovascular health. This study investigated endothelial function and its relationship with CRF in patients who have recovered COVID‐19. Patients were evaluated 1 month after infection, including clinical assessment, pulmonary function, endothelial function (measured by flow‐mediated dilation), and cardiopulmonary exercise testing. COVID‐19 survivors exhibited reduced exercise capacity, with poor values of peak V̇O2peak and FMD (%) according to disease severity. However, endothelial function was worse in COVID‐19 patients, regardless of severity, compared to the control group. Significant associations were observed between poorer FMD (%) and peak V̇O2, workload, circulatory power, and V̇O2peak/WR. Endothelial function was significantly associated with CRF in COVID‐19 patients according to disease severity. Strategies to improve CRF and reduce the negative impacts of endothelial function damage should be further investigated.https://doi.org/10.14814/phy2.70216cardiopulmonary testingCOVID‐19endothelial functionsurvivors |
| spellingShingle | Guilherme Dionir Back Murilo Rezende Oliveira Guilherme Peixoto Tinoco Arêas Patricia Faria Camargo Cássia daLuz Goulart Claudio Ricardo deOliveira José Carlos Bonjorno Junior Flávia Rossi Caruso Bonjourno Ross Arena Audrey Borghi‐Silva The impact of COVID‐19 severity on adult survivors: Is there a relationship between vascular reactivity and cardiorespiratory fitness? Physiological Reports cardiopulmonary testing COVID‐19 endothelial function survivors |
| title | The impact of COVID‐19 severity on adult survivors: Is there a relationship between vascular reactivity and cardiorespiratory fitness? |
| title_full | The impact of COVID‐19 severity on adult survivors: Is there a relationship between vascular reactivity and cardiorespiratory fitness? |
| title_fullStr | The impact of COVID‐19 severity on adult survivors: Is there a relationship between vascular reactivity and cardiorespiratory fitness? |
| title_full_unstemmed | The impact of COVID‐19 severity on adult survivors: Is there a relationship between vascular reactivity and cardiorespiratory fitness? |
| title_short | The impact of COVID‐19 severity on adult survivors: Is there a relationship between vascular reactivity and cardiorespiratory fitness? |
| title_sort | impact of covid 19 severity on adult survivors is there a relationship between vascular reactivity and cardiorespiratory fitness |
| topic | cardiopulmonary testing COVID‐19 endothelial function survivors |
| url | https://doi.org/10.14814/phy2.70216 |
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