Associations of frailty and cognitive impairment with all-cause and cardiovascular mortality in older adults: a prospective cohort study from NHANES 2011–2014
Abstract Background The global aging trend exacerbates the challenge of frailty and cognitive impairment in older adults, yet their combined impact on health outcomes remains under-investigated. This study aims to explore how frailty and psychometric mild cognitive impairment (pMCI) jointly affect a...
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BMC
2025-02-01
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| Series: | BMC Geriatrics |
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| Online Access: | https://doi.org/10.1186/s12877-025-05752-9 |
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| author | An-Bang Liu Yan-Xia Lin Guan-Ying Li Ting-Ting Meng Peng Tian Jian-Lin Chen Xin-He Zhang Wei-Hong Xu Yu Zhang Dan Zhang Yan Zheng |
| author_facet | An-Bang Liu Yan-Xia Lin Guan-Ying Li Ting-Ting Meng Peng Tian Jian-Lin Chen Xin-He Zhang Wei-Hong Xu Yu Zhang Dan Zhang Yan Zheng |
| author_sort | An-Bang Liu |
| collection | DOAJ |
| description | Abstract Background The global aging trend exacerbates the challenge of frailty and cognitive impairment in older adults, yet their combined impact on health outcomes remains under-investigated. This study aims to explore how frailty and psychometric mild cognitive impairment (pMCI) jointly affect all-cause and cardiovascular disease (CVD) mortality. Methods The cohort study we examined 2,442 participants aged ≥ 60, is the secondary analysis from the National Health and Nutrition Examination Survey (NHANES) 2011–2014. Frailty was quantified using a 49-item frailty index, while pMCI was determined by three composite cognition scores one standard deviation (SD) below the mean. The associations between frailty, pMCI, comorbidity, and mortality were assessed using weighted Cox proportional hazards models. Results Of the participants, 31.37% were frail, 17.2% had pMCI, and 8.64% exhibited both conditions. The cohort was stratified into four groups based on frailty and pMCI status. After a median follow-up period of 6.5 years, frail individuals with pMCI had the highest all-cause (75.23 per 1,000 person-years) and CVD (32.97 per 1,000 person-years) mortality rates. Adjusted hazard ratios (HRs) for all-cause (3.06; 95% CI, 2.05–4.56) and CVD (3.8; 95% CI, 2.07–6.96) mortality were highest in frail older adults with pMCI compared to those who were non-frail without pMCI. Conclusion Our study highlights the ubiquity of frailty and cognitive impairment in older adults and underscores the heightened risk of mortality associated with their coexistence. These findings suggest the critical need for proactive screening and management of frailty and cognitive function in clinical practice to improve outcomes for the older adults. |
| format | Article |
| id | doaj-art-54c59342f55f405f81fee468bef88f2d |
| institution | DOAJ |
| issn | 1471-2318 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj-art-54c59342f55f405f81fee468bef88f2d2025-08-20T03:11:07ZengBMCBMC Geriatrics1471-23182025-02-0125111010.1186/s12877-025-05752-9Associations of frailty and cognitive impairment with all-cause and cardiovascular mortality in older adults: a prospective cohort study from NHANES 2011–2014An-Bang Liu0Yan-Xia Lin1Guan-Ying Li2Ting-Ting Meng3Peng Tian4Jian-Lin Chen5Xin-He Zhang6Wei-Hong Xu7Yu Zhang8Dan Zhang9Yan Zheng10Research Center of Translational Medicine, Central Hospital Affiliated to Shandong First Medical UniversityResearch Center of Translational Medicine, Central Hospital Affiliated to Shandong First Medical UniversityJinan Foreign Language School International CenterResearch Center of Translational Medicine, Central Hospital Affiliated to Shandong First Medical UniversityDepartment of Cardiology, Central Hospital Affiliated to Shandong First Medical UniversityDepartment of Cardiology, Central Hospital Affiliated to Shandong First Medical UniversityResearch Center of Translational Medicine, Central Hospital Affiliated to Shandong First Medical UniversityResearch Center of Translational Medicine, Central Hospital Affiliated to Shandong First Medical UniversityResearch Center of Translational Medicine, Central Hospital Affiliated to Shandong First Medical UniversityDepartment of Cardiology, Central Hospital Affiliated to Shandong First Medical UniversityResearch Center of Translational Medicine, Central Hospital Affiliated to Shandong First Medical UniversityAbstract Background The global aging trend exacerbates the challenge of frailty and cognitive impairment in older adults, yet their combined impact on health outcomes remains under-investigated. This study aims to explore how frailty and psychometric mild cognitive impairment (pMCI) jointly affect all-cause and cardiovascular disease (CVD) mortality. Methods The cohort study we examined 2,442 participants aged ≥ 60, is the secondary analysis from the National Health and Nutrition Examination Survey (NHANES) 2011–2014. Frailty was quantified using a 49-item frailty index, while pMCI was determined by three composite cognition scores one standard deviation (SD) below the mean. The associations between frailty, pMCI, comorbidity, and mortality were assessed using weighted Cox proportional hazards models. Results Of the participants, 31.37% were frail, 17.2% had pMCI, and 8.64% exhibited both conditions. The cohort was stratified into four groups based on frailty and pMCI status. After a median follow-up period of 6.5 years, frail individuals with pMCI had the highest all-cause (75.23 per 1,000 person-years) and CVD (32.97 per 1,000 person-years) mortality rates. Adjusted hazard ratios (HRs) for all-cause (3.06; 95% CI, 2.05–4.56) and CVD (3.8; 95% CI, 2.07–6.96) mortality were highest in frail older adults with pMCI compared to those who were non-frail without pMCI. Conclusion Our study highlights the ubiquity of frailty and cognitive impairment in older adults and underscores the heightened risk of mortality associated with their coexistence. These findings suggest the critical need for proactive screening and management of frailty and cognitive function in clinical practice to improve outcomes for the older adults.https://doi.org/10.1186/s12877-025-05752-9FrailtyCognitionPsychometric mild cognitive impairmentMortalityOlder adults |
| spellingShingle | An-Bang Liu Yan-Xia Lin Guan-Ying Li Ting-Ting Meng Peng Tian Jian-Lin Chen Xin-He Zhang Wei-Hong Xu Yu Zhang Dan Zhang Yan Zheng Associations of frailty and cognitive impairment with all-cause and cardiovascular mortality in older adults: a prospective cohort study from NHANES 2011–2014 BMC Geriatrics Frailty Cognition Psychometric mild cognitive impairment Mortality Older adults |
| title | Associations of frailty and cognitive impairment with all-cause and cardiovascular mortality in older adults: a prospective cohort study from NHANES 2011–2014 |
| title_full | Associations of frailty and cognitive impairment with all-cause and cardiovascular mortality in older adults: a prospective cohort study from NHANES 2011–2014 |
| title_fullStr | Associations of frailty and cognitive impairment with all-cause and cardiovascular mortality in older adults: a prospective cohort study from NHANES 2011–2014 |
| title_full_unstemmed | Associations of frailty and cognitive impairment with all-cause and cardiovascular mortality in older adults: a prospective cohort study from NHANES 2011–2014 |
| title_short | Associations of frailty and cognitive impairment with all-cause and cardiovascular mortality in older adults: a prospective cohort study from NHANES 2011–2014 |
| title_sort | associations of frailty and cognitive impairment with all cause and cardiovascular mortality in older adults a prospective cohort study from nhanes 2011 2014 |
| topic | Frailty Cognition Psychometric mild cognitive impairment Mortality Older adults |
| url | https://doi.org/10.1186/s12877-025-05752-9 |
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