Exploring the heterogeneity of HER2 gene status and expression in non-positive breast cancer patients: insights from immunohistochemistry and fluorescence in situ hybridization

Exploring the heterogeneity of HER2 gene status and expression in non-positive breast cancer patients: insights from immunohistochemistry and fluorescence in situ hybridization

Abstract Breast cancer became the most prevalent malignancy among women, and HER2 expression status is critical for treatment decisions. With the emergence of ADC drugs, HER2 low-expressing patients who previously did not respond well to traditional anti-HER2 therapies may now benefit. In this study...

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Bibliographic Details
Main Authors: Jingmin Zhong, Beibei Gao, Qingjie Wang, Jun He, Danjv Luo, Chen Zhang, Jun Fan, Xiu Nie
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Diagnostic Pathology
Subjects:
Breast cancer
HER2-low
FISH
Immunohistochemistry staining
Online Access:https://doi.org/10.1186/s13000-024-01594-y
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