An explorative study on the interaction of cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1/ANRIL) gene polymorphism with obesity on periodontitis among Norwegian adults
Objective ANRIL is a pleiotropic gene with a strong link to periodontitis. ANRIL gene variant rs1537373 is associated with altered CDKN2B gene expression, which is linked to obesity. In this explorative, cross-sectional population-based study, we aimed to investigate the hypothesis that ANRIL (rs15...
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Medical Journals Sweden
2025-08-01
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| Series: | Acta Odontologica Scandinavica |
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| Online Access: | https://medicaljournalssweden.se/actaodontologica/article/view/44368 |
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| author | Natalia Petrenya Laila A. Hopstock Elin Hadler-Olsen Farah Asa'ad Lena Larsson Gro Eirin Holde Alexandre R Vieira Birgitta Jönsson |
| author_facet | Natalia Petrenya Laila A. Hopstock Elin Hadler-Olsen Farah Asa'ad Lena Larsson Gro Eirin Holde Alexandre R Vieira Birgitta Jönsson |
| author_sort | Natalia Petrenya |
| collection | DOAJ |
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Objective ANRIL is a pleiotropic gene with a strong link to periodontitis. ANRIL gene variant rs1537373 is associated with altered CDKN2B gene expression, which is linked to obesity. In this explorative, cross-sectional population-based study, we aimed to investigate the hypothesis that ANRIL (rs1537373) T>G may be associated with periodontitis through interactions, focusing on rs1537373×obesity interaction.
Methods Genotyping for ANRIL (rs1537373), and clinical and periodontal examination were performed in 3554 participants (aged 40-93 years, 52% women) from the seventh survey of the Tromsø Study (2015–2016), Norway. We defined periodontitis stage based on radiographic bone loss (2018 AAP/EFP classification).
Results The individual association between rs1537373 and periodontitis, as well as multiplicative and additive interactions between rs1537373 and age, sex, smoking, and obesity on periodontitis under a recessive model were studied. We found multiplicative and additive interactions between rs1537373 and obesity. When compared with GT/TT genotype and no obesity, GG genotype and obesity was associated with higher odds for periodontitis stage III-IV (OR=2.47, 95%CI=1.48-4.12, p=0.001; relative excess risk due to interaction=1.51, 95%CI=0.26-2.77, p=0.018; attributable proportion due to interaction=0.61; 95%CI=0.35-0.87, p<0.001).
Conclusion Our findings suggest that rs1537373 GG genotype and obesity were jointly associated with periodontitis stage III-IV in this Norwegian population.
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| format | Article |
| id | doaj-art-54bf710a020b43efaccaeda57e8d2a63 |
| institution | DOAJ |
| issn | 0001-6357 1502-3850 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Odontologica Scandinavica |
| spelling | doaj-art-54bf710a020b43efaccaeda57e8d2a632025-08-20T03:04:50ZengMedical Journals SwedenActa Odontologica Scandinavica0001-63571502-38502025-08-018410.2340/aos.v84.44368An explorative study on the interaction of cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1/ANRIL) gene polymorphism with obesity on periodontitis among Norwegian adultsNatalia Petrenya0Laila A. Hopstock1Elin Hadler-Olsen2Farah Asa'ad3Lena Larsson4Gro Eirin Holde5Alexandre R Vieira6Birgitta Jönsson7The Public Dental Health Service Competence Centre of Northern Norway, Tromsø, NorwayDepartment of Health and Care Sciences, UiT The Arctic University of Norway, Tromsø, NorwayThe Public Dental Health Service Competence Centre of Northern Norway, Tromsø, Norway; Department of Medical Biology, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, NorwayDepartment of Oral Biochemistry, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenDepartment of Oral Biochemistry, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenThe Public Dental Health Service Competence Centre of Northern Norway, Tromsø, Norway; Department of Clinical Dentistry, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, NorwaySchool of Dental Medicine, East Carolina University, Greenville, NC, USAThe Public Dental Health Service Competence Centre of Northern Norway, Tromsø, Norway; Department of Periodontology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Objective ANRIL is a pleiotropic gene with a strong link to periodontitis. ANRIL gene variant rs1537373 is associated with altered CDKN2B gene expression, which is linked to obesity. In this explorative, cross-sectional population-based study, we aimed to investigate the hypothesis that ANRIL (rs1537373) T>G may be associated with periodontitis through interactions, focusing on rs1537373×obesity interaction. Methods Genotyping for ANRIL (rs1537373), and clinical and periodontal examination were performed in 3554 participants (aged 40-93 years, 52% women) from the seventh survey of the Tromsø Study (2015–2016), Norway. We defined periodontitis stage based on radiographic bone loss (2018 AAP/EFP classification). Results The individual association between rs1537373 and periodontitis, as well as multiplicative and additive interactions between rs1537373 and age, sex, smoking, and obesity on periodontitis under a recessive model were studied. We found multiplicative and additive interactions between rs1537373 and obesity. When compared with GT/TT genotype and no obesity, GG genotype and obesity was associated with higher odds for periodontitis stage III-IV (OR=2.47, 95%CI=1.48-4.12, p=0.001; relative excess risk due to interaction=1.51, 95%CI=0.26-2.77, p=0.018; attributable proportion due to interaction=0.61; 95%CI=0.35-0.87, p<0.001). Conclusion Our findings suggest that rs1537373 GG genotype and obesity were jointly associated with periodontitis stage III-IV in this Norwegian population. https://medicaljournalssweden.se/actaodontologica/article/view/44368periodontitisobesityANRIL long non-coding RNAsingle nucleotide polymorphismgenetic variation |
| spellingShingle | Natalia Petrenya Laila A. Hopstock Elin Hadler-Olsen Farah Asa'ad Lena Larsson Gro Eirin Holde Alexandre R Vieira Birgitta Jönsson An explorative study on the interaction of cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1/ANRIL) gene polymorphism with obesity on periodontitis among Norwegian adults Acta Odontologica Scandinavica periodontitis obesity ANRIL long non-coding RNA single nucleotide polymorphism genetic variation |
| title | An explorative study on the interaction of cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1/ANRIL) gene polymorphism with obesity on periodontitis among Norwegian adults |
| title_full | An explorative study on the interaction of cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1/ANRIL) gene polymorphism with obesity on periodontitis among Norwegian adults |
| title_fullStr | An explorative study on the interaction of cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1/ANRIL) gene polymorphism with obesity on periodontitis among Norwegian adults |
| title_full_unstemmed | An explorative study on the interaction of cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1/ANRIL) gene polymorphism with obesity on periodontitis among Norwegian adults |
| title_short | An explorative study on the interaction of cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1/ANRIL) gene polymorphism with obesity on periodontitis among Norwegian adults |
| title_sort | explorative study on the interaction of cyclin dependent kinase inhibitor 2b antisense rna 1 cdkn2b as1 anril gene polymorphism with obesity on periodontitis among norwegian adults |
| topic | periodontitis obesity ANRIL long non-coding RNA single nucleotide polymorphism genetic variation |
| url | https://medicaljournalssweden.se/actaodontologica/article/view/44368 |
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