Effect of Electroacupuncture at Baihui Acupoint on Magnetic Resonance Spectroscopy and Spatial Learning and Memory Ability in APP/PS1 Transgenic Mice
Objective:To investigate the effects of electroacupuncture (EA) at Baihui (DU20) acupoint on learning and memory ability and<sup>1</sup>H magnetic resonance spectroscopy (<sup>1</sup>H-MRS) in APP/PS1 transgenic mice.Methods:A male APP/PS1 transgenic mice mated with a wild ty...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Editorial Office of Rehabilitation Medicine
2016-10-01
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| Series: | 康复学报 |
| Subjects: | |
| Online Access: | http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2016.05042 |
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| Summary: | Objective:To investigate the effects of electroacupuncture (EA) at Baihui (DU20) acupoint on learning and memory ability and<sup>1</sup>H magnetic resonance spectroscopy (<sup>1</sup>H-MRS) in APP/PS1 transgenic mice.Methods:A male APP/PS1 transgenic mice mated with a wild type female mice and 15 bred APP/PS1 transgenic mice identified by PCR were randomly divided into the model group (<italic>n</italic>=7) and the EA group (<italic>n</italic>=8) according to a random number table, and 8 age-matched littermates were divided into the control group. The EA group received EA at Baihui acupoint for 4 weeks. Morris water maze was used to test spatial learning and memory ability in the fourth week. NAA, Glu of the hippocampus were detected by<sup>1</sup>H-MRS.Results:Compared with the model group, the level of NAA and Glu were significantly increased (<italic>P</italic><0.05). The EA group also ameliorated spatial learning and memory ability (<italic>P</italic><0.05).Conclusion:EA at Baihui acupoint can improve spatial learning and memory ability inAPP/PS1 transgenic mice, the mechanism may be associated with the increasing NAA and Glu of the hippocampus. |
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| ISSN: | 2096-0328 |