Comparative immunologic profiling of mRNA and protein-conjugated vaccines: acute inflammatory responses and anti-PEG antibody production
Messenger ribonucleic acid (mRNA) vaccines have become a prevalent immunization method, even as the coronavirus disease 2019 (COVID-19) pandemic recedes. However, the potential adverse effects using mRNA vaccines need to be explored in this evolving landscape. In this study, 60 participants were ran...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Animal Cells and Systems |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19768354.2025.2510984 |
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| author | Gahyun Roh Jisun Lee Hyun-Mee Park Woori Kwak Hyo-Jung Park Ayoung Oh Yewon Na Dahyeon Ha Yu-Sun Lee Seo-Hyeon Bae Seonghyun Lee Subin Yoon Sowon Lee Jaehun Jung Jacob Lee Jae-Hwan Nam |
| author_facet | Gahyun Roh Jisun Lee Hyun-Mee Park Woori Kwak Hyo-Jung Park Ayoung Oh Yewon Na Dahyeon Ha Yu-Sun Lee Seo-Hyeon Bae Seonghyun Lee Subin Yoon Sowon Lee Jaehun Jung Jacob Lee Jae-Hwan Nam |
| author_sort | Gahyun Roh |
| collection | DOAJ |
| description | Messenger ribonucleic acid (mRNA) vaccines have become a prevalent immunization method, even as the coronavirus disease 2019 (COVID-19) pandemic recedes. However, the potential adverse effects using mRNA vaccines need to be explored in this evolving landscape. In this study, 60 participants were randomly assigned to receive either an mRNA vaccine, specifically for COVID-19, or a conventional vaccine for meningococcal disease. Symptom records and blood samples were collected on Days 0, 3, and 7 after vaccination. Results showed that recipients of mRNA vaccines exhibited elevated levels of serum acute-phase proteins, such as haptoglobin and C-reactive protein, alongside decreased white blood cell counts compared to those receiving conventional vaccines. Proteomic analysis identified significant changes in nine proteins, including interactions involving complement component C9, haptoglobin, and alpha-1-acid glycoprotein, suggesting implications for complement activation and inflammatory responses. Furthermore, variability in anti-polyethylene glycol antibody levels was noted among mRNA vaccine recipients compared to conventional vaccine recipients. This research aims to provide useful information to help develop future vaccination strategies and shape research directions to mitigate individual adverse effects. |
| format | Article |
| id | doaj-art-54bb41ed149a45d99dd6d854a67f8a17 |
| institution | Kabale University |
| issn | 1976-8354 2151-2485 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Animal Cells and Systems |
| spelling | doaj-art-54bb41ed149a45d99dd6d854a67f8a172025-08-20T03:44:57ZengTaylor & Francis GroupAnimal Cells and Systems1976-83542151-24852025-12-0129138740110.1080/19768354.2025.2510984Comparative immunologic profiling of mRNA and protein-conjugated vaccines: acute inflammatory responses and anti-PEG antibody productionGahyun Roh0Jisun Lee1Hyun-Mee Park2Woori Kwak3Hyo-Jung Park4Ayoung Oh5Yewon Na6Dahyeon Ha7Yu-Sun Lee8Seo-Hyeon Bae9Seonghyun Lee10Subin Yoon11Sowon Lee12Jaehun Jung13Jacob Lee14Jae-Hwan Nam15Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of KoreaDepartment of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of KoreaAdvanced Analysis and Data Center, Korea Institute of Science and Technology, Seoul, Republic of KoreaDepartment of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of KoreaDepartment of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of KoreaDepartment of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of KoreaDepartment of Preventive Medicine, Gachon University College of Medicine, Incheon, Republic of KoreaDepartment of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of KoreaDepartment of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of KoreaDepartment of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of KoreaDepartment of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of KoreaDepartment of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of KoreaDepartment of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of KoreaDepartment of Preventive Medicine, Gachon University College of Medicine, Incheon, Republic of KoreaDivision of Infectious Disease, Department of Internal Medicine, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Republic of KoreaDepartment of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of KoreaMessenger ribonucleic acid (mRNA) vaccines have become a prevalent immunization method, even as the coronavirus disease 2019 (COVID-19) pandemic recedes. However, the potential adverse effects using mRNA vaccines need to be explored in this evolving landscape. In this study, 60 participants were randomly assigned to receive either an mRNA vaccine, specifically for COVID-19, or a conventional vaccine for meningococcal disease. Symptom records and blood samples were collected on Days 0, 3, and 7 after vaccination. Results showed that recipients of mRNA vaccines exhibited elevated levels of serum acute-phase proteins, such as haptoglobin and C-reactive protein, alongside decreased white blood cell counts compared to those receiving conventional vaccines. Proteomic analysis identified significant changes in nine proteins, including interactions involving complement component C9, haptoglobin, and alpha-1-acid glycoprotein, suggesting implications for complement activation and inflammatory responses. Furthermore, variability in anti-polyethylene glycol antibody levels was noted among mRNA vaccine recipients compared to conventional vaccine recipients. This research aims to provide useful information to help develop future vaccination strategies and shape research directions to mitigate individual adverse effects.https://www.tandfonline.com/doi/10.1080/19768354.2025.2510984mRNACOVID-19 vaccinationmeningococcal vaccinesC-reactive proteinhaptoglobin |
| spellingShingle | Gahyun Roh Jisun Lee Hyun-Mee Park Woori Kwak Hyo-Jung Park Ayoung Oh Yewon Na Dahyeon Ha Yu-Sun Lee Seo-Hyeon Bae Seonghyun Lee Subin Yoon Sowon Lee Jaehun Jung Jacob Lee Jae-Hwan Nam Comparative immunologic profiling of mRNA and protein-conjugated vaccines: acute inflammatory responses and anti-PEG antibody production Animal Cells and Systems mRNA COVID-19 vaccination meningococcal vaccines C-reactive protein haptoglobin |
| title | Comparative immunologic profiling of mRNA and protein-conjugated vaccines: acute inflammatory responses and anti-PEG antibody production |
| title_full | Comparative immunologic profiling of mRNA and protein-conjugated vaccines: acute inflammatory responses and anti-PEG antibody production |
| title_fullStr | Comparative immunologic profiling of mRNA and protein-conjugated vaccines: acute inflammatory responses and anti-PEG antibody production |
| title_full_unstemmed | Comparative immunologic profiling of mRNA and protein-conjugated vaccines: acute inflammatory responses and anti-PEG antibody production |
| title_short | Comparative immunologic profiling of mRNA and protein-conjugated vaccines: acute inflammatory responses and anti-PEG antibody production |
| title_sort | comparative immunologic profiling of mrna and protein conjugated vaccines acute inflammatory responses and anti peg antibody production |
| topic | mRNA COVID-19 vaccination meningococcal vaccines C-reactive protein haptoglobin |
| url | https://www.tandfonline.com/doi/10.1080/19768354.2025.2510984 |
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