Limbal stem cell deficiency diagnostics
Relevance. Limbal stem cell deficiency (LSCD) is a pathology that leads to substantial vision decrease, corneal neovascularization, corneal epithelial persistent erosions and have a negative impact on patient’s the quality of life. It is known that the efficiency of corneal transplantation in LSCD p...
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| Format: | Article |
| Language: | Russian |
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Publishing house "Ophthalmology"
2022-09-01
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| Series: | Офтальмохирургия |
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| Online Access: | https://ophthalmosurgery.ru/index.php/ophthalmosurgery/article/view/374/419 |
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| author | B.E. Malyugin S.A. Borzenok S.Yu. Kalinnikova M.Yu. Gerasimov |
| author_facet | B.E. Malyugin S.A. Borzenok S.Yu. Kalinnikova M.Yu. Gerasimov |
| author_sort | B.E. Malyugin |
| collection | DOAJ |
| description | Relevance. Limbal stem cell deficiency (LSCD) is a pathology that leads to substantial vision decrease, corneal neovascularization, corneal epithelial persistent erosions and have a negative impact on patient’s the quality of life. It is known that the efficiency of corneal transplantation in LSCD patients is low and requires repeated interventions. One of the important problems is the lack of a clear diagnostic algorithm and a standardized set of diagnostic techniques for this condition. Purpose. Systematically analyze domestic and foreign literature on the currently existing methods for diagnosing LSCD. Material and methods. A systematic analysis of scientific publications from 1992 to 2021 was carried out. Its included domestic and foreign authors on the resources of PubMed, Medline, eLibrary, as well as dissertations and textbooks devoted to currently existing methods for diagnosing LSCD. Results. In addition to biomicroscopy, the main in vivo methods for diagnosing LSCD are staining of the ocular surface, impression cytology with the detection of specific cytokeratins, confocal microscopy, optical coherence tomography of the anterior segment (OST) and OST-angiography. Conclusion. Physician awareness and vigilance are required for the diagnosis of LSCD, especially in patients with conjunctivalization and corneal neovascularization. It is impossible to use only biomicroscopy and the patient's complaints, since LSCD is not always obvious. That is why diagnostics should include an integrated approach, including all available research methods, which are briefly described in Table No. 1 with their disadvantages and advantages. |
| format | Article |
| id | doaj-art-54b5b98ebe1046b38eb39b4174c508aa |
| institution | DOAJ |
| issn | 0235-4160 2312-4970 |
| language | Russian |
| publishDate | 2022-09-01 |
| publisher | Publishing house "Ophthalmology" |
| record_format | Article |
| series | Офтальмохирургия |
| spelling | doaj-art-54b5b98ebe1046b38eb39b4174c508aa2025-08-20T03:02:55ZrusPublishing house "Ophthalmology"Офтальмохирургия0235-41602312-49702022-09-013829710.25276/0235-4160-2022-3-82-97Limbal stem cell deficiency diagnosticsB.E. Malyugin0https://orcid.org/0000-0001-5666-3493S.A. Borzenok1https://orcid.org/0000-0001-9160-6240S.Yu. Kalinnikova2https://orcid.org/0000-0002-9109-2400M.Yu. Gerasimov3https://orcid.org/0000-0003-3433-8352Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation; Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russian FederationFyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation; Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russian FederationFyodorov Eye Microsurgery Federal State Institution, Moscow, Russian FederationFyodorov Eye Microsurgery Federal State Institution, Moscow, Russian FederationRelevance. Limbal stem cell deficiency (LSCD) is a pathology that leads to substantial vision decrease, corneal neovascularization, corneal epithelial persistent erosions and have a negative impact on patient’s the quality of life. It is known that the efficiency of corneal transplantation in LSCD patients is low and requires repeated interventions. One of the important problems is the lack of a clear diagnostic algorithm and a standardized set of diagnostic techniques for this condition. Purpose. Systematically analyze domestic and foreign literature on the currently existing methods for diagnosing LSCD. Material and methods. A systematic analysis of scientific publications from 1992 to 2021 was carried out. Its included domestic and foreign authors on the resources of PubMed, Medline, eLibrary, as well as dissertations and textbooks devoted to currently existing methods for diagnosing LSCD. Results. In addition to biomicroscopy, the main in vivo methods for diagnosing LSCD are staining of the ocular surface, impression cytology with the detection of specific cytokeratins, confocal microscopy, optical coherence tomography of the anterior segment (OST) and OST-angiography. Conclusion. Physician awareness and vigilance are required for the diagnosis of LSCD, especially in patients with conjunctivalization and corneal neovascularization. It is impossible to use only biomicroscopy and the patient's complaints, since LSCD is not always obvious. That is why diagnostics should include an integrated approach, including all available research methods, which are briefly described in Table No. 1 with their disadvantages and advantages.https://ophthalmosurgery.ru/index.php/ophthalmosurgery/article/view/374/419imbal stem cell deficiencyimpression cytologylaser confocal scanning microscopygoblet cellscytokeratinpenetrating keratoplastycytokines |
| spellingShingle | B.E. Malyugin S.A. Borzenok S.Yu. Kalinnikova M.Yu. Gerasimov Limbal stem cell deficiency diagnostics Офтальмохирургия imbal stem cell deficiency impression cytology laser confocal scanning microscopy goblet cells cytokeratin penetrating keratoplasty cytokines |
| title | Limbal stem cell deficiency diagnostics |
| title_full | Limbal stem cell deficiency diagnostics |
| title_fullStr | Limbal stem cell deficiency diagnostics |
| title_full_unstemmed | Limbal stem cell deficiency diagnostics |
| title_short | Limbal stem cell deficiency diagnostics |
| title_sort | limbal stem cell deficiency diagnostics |
| topic | imbal stem cell deficiency impression cytology laser confocal scanning microscopy goblet cells cytokeratin penetrating keratoplasty cytokines |
| url | https://ophthalmosurgery.ru/index.php/ophthalmosurgery/article/view/374/419 |
| work_keys_str_mv | AT bemalyugin limbalstemcelldeficiencydiagnostics AT saborzenok limbalstemcelldeficiencydiagnostics AT syukalinnikova limbalstemcelldeficiencydiagnostics AT myugerasimov limbalstemcelldeficiencydiagnostics |