Genetic Contribution to the Pathogenesis of Primary Biliary Cholangitis
Formerly termed primary biliary cirrhosis, primary biliary cholangitis (PBC) is a chronic and progressive cholestatic liver disease characterized by the presence of antimitochondrial antibodies. Ursodeoxycholic acid (UDCA) therapy is the most effective and approved treatment for PBC and leads to a f...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/3073504 |
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| author | Satoru Joshita Takeji Umemura Eiji Tanaka Masao Ota |
| author_facet | Satoru Joshita Takeji Umemura Eiji Tanaka Masao Ota |
| author_sort | Satoru Joshita |
| collection | DOAJ |
| description | Formerly termed primary biliary cirrhosis, primary biliary cholangitis (PBC) is a chronic and progressive cholestatic liver disease characterized by the presence of antimitochondrial antibodies. Ursodeoxycholic acid (UDCA) therapy is the most effective and approved treatment for PBC and leads to a favorable outcome in the vast majority of cases. Although the etiology of PBC has not yet been elucidated, human leukocyte antigen (HLA) class II alleles have been consistently associated with disease onset for decades. Individuals in different geographic regions of the world may have varying susceptibility alleles that reflect indigenous triggering antigens. In this review, we describe the influence of HLA alleles and other gene polymorphisms on PBC along with the results of genome-wide association studies (GWAS) on this disease. |
| format | Article |
| id | doaj-art-54b52e1ecdd246149e61c735abdc623b |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-54b52e1ecdd246149e61c735abdc623b2025-02-03T05:53:32ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/30735043073504Genetic Contribution to the Pathogenesis of Primary Biliary CholangitisSatoru Joshita0Takeji Umemura1Eiji Tanaka2Masao Ota3Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, JapanDepartment of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, JapanDepartment of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, JapanDepartment of Legal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, JapanFormerly termed primary biliary cirrhosis, primary biliary cholangitis (PBC) is a chronic and progressive cholestatic liver disease characterized by the presence of antimitochondrial antibodies. Ursodeoxycholic acid (UDCA) therapy is the most effective and approved treatment for PBC and leads to a favorable outcome in the vast majority of cases. Although the etiology of PBC has not yet been elucidated, human leukocyte antigen (HLA) class II alleles have been consistently associated with disease onset for decades. Individuals in different geographic regions of the world may have varying susceptibility alleles that reflect indigenous triggering antigens. In this review, we describe the influence of HLA alleles and other gene polymorphisms on PBC along with the results of genome-wide association studies (GWAS) on this disease.http://dx.doi.org/10.1155/2017/3073504 |
| spellingShingle | Satoru Joshita Takeji Umemura Eiji Tanaka Masao Ota Genetic Contribution to the Pathogenesis of Primary Biliary Cholangitis Journal of Immunology Research |
| title | Genetic Contribution to the Pathogenesis of Primary Biliary Cholangitis |
| title_full | Genetic Contribution to the Pathogenesis of Primary Biliary Cholangitis |
| title_fullStr | Genetic Contribution to the Pathogenesis of Primary Biliary Cholangitis |
| title_full_unstemmed | Genetic Contribution to the Pathogenesis of Primary Biliary Cholangitis |
| title_short | Genetic Contribution to the Pathogenesis of Primary Biliary Cholangitis |
| title_sort | genetic contribution to the pathogenesis of primary biliary cholangitis |
| url | http://dx.doi.org/10.1155/2017/3073504 |
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