HLA-E/Mtb specific CD4+ and CD8+ T cells have a memory phenotype in individuals with TB infection

HLA-E/Mtb specific CD4+ and CD8+ T cells have a memory phenotype in individuals with TB infection

IntroductionTuberculosis (TB) is the deadliest infectious disease worldwide and novel vaccines are urgently needed. HLA-E is a virtually monomorphic antigen presentation molecule and is not downregulated upon HIV co-infection. HLA-E restricted Mtb specific CD8+ T cells are present in the circulation...

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Bibliographic Details
Main Authors: Linda Voogd, Catherine Riou, Thomas J. Scriba, Marjolein van Wolfswinkel, Krista E. van Meijgaarden, Kees L. M. C. Franken, Robert J. Wilkinson, Tom H. M. Ottenhoff, Simone A. Joosten
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
Tuberculosis
HLA-E
T cells
immunophenotyping
spectral flow cytometry
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1505329/full
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